2008-06-30

Section 2-4. Life begins with eating. Eating is a center for living bodies

This can also be compared to the evolution from unicellular animals to humans. Starting from protozoa including amoeba in which predatory activities played a central role, the evolution occurred to protochordate, cartilaginous fish, and finally mammals. Expansion of new functions during the course of evolution did not occur only by sudden addition of new functions independent from the existing organs but by upgrading of the whole systems in the forms of expansion and differentiation of functions. Accordingly, the primordal system in which the predatory organs play a central role in the life activities would not be changed even if this system becomes complicated or any new organs and new functions are added. Prandial activities are the central one for any lives.
In the process of actual evolution, cephalic and visceral skeletons and muscles are called as “gill arch organs” and it was known that they derived from gills. When it comes to gills, gills in animals just before evolution to vertebrates or the initial verbrates did not contribute to only respiration but worked as predatory organs or digestive organs to get nutrition through filtering planktons from water. Respiration was mainly performed via mucoid membranes on the body surface. Vestigial evidence is now observed in a fish which resembles lancelet belonging to protochordates. Although brain is recognized as the center of the body, the brain in the initial stages of evolution of vertebras was only a lump comprising nervous cells. In the course of evolution, this lump evolved into much more complicated structure consisting of cerebrum, interbrain, mid brain, cerebellum and medulla.
However, instead of pursuing the center of human lives, questions were centered on where mental activities such as thinking, worrying, pleased or agony are produced for a long time among the well-educated persons. As the natural consequence, no discussion on the center of our lives or the basis of our bodies was conducted whereby we misunderstood that the point where our heart exists was regarded as the center of our bodies. Hippocrates (427 B.C.~347 B.C.) and Plato (427 B.C.~347 B.C.) stated “Our soul exists in the brain”. This concept was adopted to the religious principle of Christianity and then, “Brain center theory” was propagated. Subsequently, in parallel with advance of the cephalic physiology, the central functions of the brain were gradually clarified, and furthermore, the center of the living body was considered to be localized in the brain. Taking into account the progress of evolution, it could be explained by the Brain center theory; however, it would be more rational to attribute the center of the living body to the brain, special sensory organs like eyes, and the whole head containing the predacious organs including teeth and tongue. Chewing organs structurally comprise a part of the cranial bone as the jaw joint while chewing muscles are adhered to the cranial bone. Given the evolution process of the “gill arch organs”, it seems appropriate to consider that the total tissues including cranial bone, submaxillary bone, 32 teeth and the corresponding muscles and sensory organs should be recognized as “Hazo (Teeth-organ)”. Sometimes people say that heart, liver and kidney are indispensable organs for our lives but teeth are not; as the results, teeth can be disregarded in their nature. However, once teeth are evaluated from the entire “Hazo (Teeth-organ)” theory, absence of teeth indicates our deaths. Each tooth plays a role as one sensory organ which acts as the information emitting center. Eyes and ears work as a pair, respectively but teeth amount to 16 pairs. Complete sets of them exert significant contribution to the whole body functions.

2008-06-27

Section 2-3. “Hazo” is a linchpin for muscles in the whole body

Among lots of joints in our body, only sacroiliac joint and mandibular joint are bilaterally located around the midline (Figure 47). When we take a standing posture against gravity and atmospheric pressure, these two joints play a definitive role as the linchpin for all the muscles including anti-gravity muscles because these joints are located symmetrically around the midline. Particularly, “mandibular joint” is closely correlated with a group of muscles in the head and neck which support the head, besides being capable to move flexibly unlike the sacroiliac joint. Accordingly, whenever we bend forward or backward, it is conceivable that these joints exhibit important functions as “balancer” for the whole muscles in the body. It is obvious from the so far reported study results on electromyograms that the chewing muscles and muscles located in the head and neck areas with general muscles in the body coordinate each other as one system. In more details, it was evidenced that tension of chewing muscles generates simultaneous involuntary discharge in various skeletal muscles in the body to always induce increased muscular tonus. It was also documented that electric discharge occurred in the remote muscles from teeth, such as extensor muscle of the forearm and gastrocnemium muscles in legs.
In relation to the fact that systemic muscles are involved in “Hazo” mechanisms, Dr. Noguchi Michizo mentioned in his book entitled with “Noguchi gymnastic exercises are effective for physical conditions” (Hakuju Sha) that “Our body is a living wineskin”, namely “In living human bodies, body fluids are packed in a living skin bag in which bones and visceral organs are floating.” It seems that muscles have hardness to support the skin and temperature maintenance effects. In talking about the skin bag, there should be an inlet and an outlet. Yes, there are a mouth and an anus. The skin bag is tightly closed with these inlets. In the book written by Tenpu Nakamura, there is an expression “You must constrict your anus with attention on muscles”.
I wish to review the concept comparing to the wineskin by referring to the fundamental structure of humans. The basic structure of humans comprises the vertebral column traversing the trunk longitudinally, “Central nerves” lying dorsal to the column and “Digestive tracts” located ventral to the column starting from mouth to anus. This structure is commonly observed in the fish ancestors who appeared on the earth about 570 thousand years ago, and their descendant vertebrates. In other words, human bodies resemble “macaroni” in that digestive tracts penetrate the human bodies. Surrounding these digestive tracts, “visceral organs” gather together and “body wall” covers them. If we compare human bodies to the wineskin, the body is called as a double-structure, with the internal wineskin called as the digestive tracts having mouth and anus at both ends. The muscles under this wineskin are connected mutually, indicating a system. Incidentally, under the outer wineskin there are lots of skeletal muscles while under the internal wineskin, there are many smooth muscles related to visceral organs.
As the linchpin of the muscle systems comprising the inlets of this wineskin, there are chewing muscles involved in moving mouth and chewing foods, suprahyoid muscles and infrahyoid muscles and other muscle groups connecting cranial bone, neck and breast. Chewing muscles consist of temporal muscle, mesenteric muscle, internal pterygoid muscle, and external pterygoid muscle. Suprahyoid muscles located above the hyoid bone consist of mylohyoid muscle, digastric muscle, stylohyoid muscle and geniohyoid while infrahyoid muscles, located below the hyoid bone comprise thyrohyoid muscle, sternomastoid muscle, sternohyoid muscle and omohyoid muscle. Contraction of suprahyoid muscles and infrahyoid muscles is associated with lowering of lower jaw resulting in causing the opening movement. At this occasion, chewing muscles as the antagonizing muscle are relaxed. Subsequent contraction of chewing muscles induces opening movement and chewing movements. The muscles connecting other cranial bones with cervical and thoracic parts consist of platysma, sternocleidomastoid muscle, rectus capitis posterior major muscle, rectus capitis posterior minor muscle, obliquus capitis superior muscle and obliquus capitis inferior muscle. The ligaments of these muscles work as the string are considered to loose or close the wineskin. In the similar manners as the human body is regarded as one micro-cosmos, muscle systems are not sufficient to complete the systemic systems of our body but the muscle systems should be coordinated with visceral organs and other systems including meridian (the concept derived from the Oriental medicine).

2008-06-25

Section 2-2. “Hazo” controls our postures. Teeth are responsible for occurrence of low back pain and lateral curvature

Now, shall we confirm changes of the postures which are recovered by improvement of the teeth occlusion, and improvement of distorted sacrum and vertebral column? Figure 45 shows the Roentgenogram which verifies these facts. Changes of lumber vertebrae and sacrum before and after treatment are shown.
This patient, being diagnosed to have hernia, had so severe low back pain that he could not continue his works. Such pains could not be improved by mechanical traction treatment and manipulative treatment in a conventional orthopedic clinic. Accordingly, his dental occlusion was improved at our Dental office, leading to improvement of distortion of both lumber vertebrae and sacrum which were confirmed by roentgenogram. The long-lasting low back pain was also alleviated.
Already 6 years have passed since treatment but no relapse was observed. He was relieved from low back pain and has spent vivid daily life. As is obvious from this case, distortion of vertebral column was attributed to abnormal occlusion of teeth. Figure 46 shows the lateral roentgenographic findings of changes in cervical vertebra. This patient was suffering from headache, stiff shoulder and pains around neck; however, these symptoms were eliminated following dental treatment of abnormal occlusion while roentgenogram also confirmed improvement of distorted cervical vertebra.
In certain animal experiments conducted by other researchers, it was confirmed that induction of abnormal occlusion by extraction of one-sided teeth resulted in bending vertebral column of dogs. Thus, the correlation between teeth and postures was verified by animal experiments and X-ray studies on humans, suggesting that the real cause of distorted vertebral column was teeth. Once dental occlusion is distorted, the following subsequent symptoms occur such as distortion of sacrum bone, curvature of vertebral column, differences in lengths of bilateral legs and heights of bilateral shoulder, rolling and twist of the body, distortion of face and scull bone, unsymmetrical shape of face, leaning of head, lateral transition of the central axis and gravity center (Figure 47). Such distortions can be classified as shown in Figure 48, while the distorted patterns are caused by the combination of the three factors such as back-and-forth distortion, lateral distortion and rotation around the body axis. If there are any problems such as low back pain and knee pains in the lower half of the body, usually the type ○A distortion of vertebral column is observed.
These facts shall be confirmed through the letters from patients who completed dental treatment. The following letter was sent from a high-school student who suffered from lateral curvature for a long time. At his first consultation, his vertebral column showed lateral curvature, with one shoulder being abnormally lowered and the body being also leant.

Lateral curvature was pointed out at 5 years of age at the physical examination of a kindergarten. There were no subjective symptoms but my family felt some anxiety about its advance in parallel with my growth. A plastic surgery prepared the special brace and at the start of my elementary school day, I wore this brace for all the days except for gym classes. I spent constrained days.I was naturally athletic and enjoyed various sports. In particularly, I was absorbed in swimming. I received manipulative treatment concomitantly. During the manipulative treatment, I was told that application of any brace would not be good for children under growing stages and therefore, the brace was removed when I was a 4 grade elementary school boy. I started basketball for rehabilitation with objective to stretching my vertebral column. But, when I graduated the middle school, my height could not reach 170 cm (5.6 ft.). Fortunately, the angle of distortion did not advance whereas the heights of bilateral shoulders and the height of the blade bone with a stoop were different.When I was a high-school student, I knew Dr. Muratsu by introduction of my aunt.
Despite of various treatments available so far, my physical conditions could not be improved. Therefore, when I knew Dr. Muratsu, I already gave up the outcomes of his dental treatment because of my past failures. After the first treatment by Dr. Muratsu, my shoulder lines became the same bilaterally. Looking back upon the past manipulative treatments, the shoulder lines became flat but usually, the outcomes reverted to the basal conditions within 1 week and these patterns were repeated many times.One year has passed since I underwent Dr. Muratsu’s treatment. My shoulder line still remains the same bilaterally. I expected to have higher height by 10 cm if my distortion of my vertebral column is eliminated; however, I am already 17 years old, indicating that my growth period is almost around the final corner. I started to enjoy rugby when I was a high-school boy and my physical condition is well-muscled. If I met Dr. Muratsu 2~3 years before, I should have had higher height. Since Dr. Muratsu is conducting an epoch-making study and therefore, if my experience is propagated to other persons who are suffering from various diseases, I am quite sure that this will be good news to them. I really hope the future activities.
(A 17-year-old high-school student, Kumamoto)


For about 20 years, I was suffering from low back pain. However, thanks to dental treatment of abnormal occlusion, low back pains were eliminated. Thank you very much.KOS Muratsu Dental Clinic was introduced by one of my colleagues. I was really lucky. Although I received manipulative treatment and osteopathy, tentative cure was obtained but symptoms relapsed many times. I could not stand for a long time and I felt tiredness when I went out. I also was anxious about my old age, namely, what will happen if such a low back pain persists in future.Low back pain was alleviated while treatment of dental caries was completed. I appreciate
Dr. Muratsu and two colleagues. I wish to continuously receive the follow-up cares.(A 47-year-old man, Fukuoka city)


Before my dental treatment, I felt piecing pain on my right loin whenever I got up in the morning or when I stood up from a chair. After treatment of my abnormal occlusion and removal of the implanted foreign materials, such a pain completely disappeared.Before treatment, my friends told me that your right shoulder was lowered; however, after treatment, I was pointed out that my shoulder line was normalized. Previously, I could sleep only at a lateral posture but after dental treatment, I could sleep at a supine position. I fall asleep well and enjoy a sound sleep. After treatment, I felt that my body was relaxed.
(A 33-year-old woman, Munakata, Fukuoka Prefecture)



In the 17-year-old patient with lateral curvature who provided testimony, improvement was attained after 2 treatment of abnormal occlusion. Honestly speaking, the “aunt” in this letter is one of the staff members of KOS. She daily observed cures of various diseases such as distorted postures, low back pain and other systemic diseases by dental treatment. She hoped elimination of her nephew’s troubles and recommended him to receive dental treatments at KOS. As expected, her nephew’s troubles were completely cured. In these patients, their parents usually are so much concerned about their physical conditions and bring their children to plastic surgeries and big hospitals throughout the country but most of these visits were in vain. This is regarded as a blind spot of medicine. Actual causes of lateral curvature and distorted vertebral column exist on teeth. Accordingly, as far as improvement of abnormal occlusion as the real cause is achieved, lateral occlusion lasts for the remaining part of the patient’s life even if the posture is improved tentatively by manipulative treatment or traction. However, improvement of abnormal dental occlusion resulted in removal of the causes of such symptoms and therefore, symptoms could be eliminated within a short period of time. Correction of abnormality in dental fields promptly evolves into removal of long-lasting troubles; as a natural consequence, the subject patients are so much surprised.
Respective tooth exerts not only the tones associated with autonomic nervous system but also the tones affecting the physical postures. When these tones related to dental occlusion are in good harmony, well-balanced posture is produced to show no abnormal tensions. In sharp contrast, however, in case of distorted dental occlusion, confused tones travel throughout the body to induce the distorted postures and pains or various kinds of diseases and visceral disorders. Shall we further investigate why abnormal dental occlusion is so much associated with the physical postures and conditions of vertebral column?



Figure45
Recovery of the distorted lumber vertebrae and sacrum after improvement of dental occlusion
Before treatment (Right), the roentgenogram showed distorted lumber vertebrae, with sacrum being inclined; however, after improvement of dental occlusion, the lumber vertebrae was straightened with the inclination of sacrum being alleviated.



Figure46
Improvement of distorted cervical vertebra by dental treatment of abnormal occlusion
The roentgenogram (Right) before treatment showed abnormal curvature of cervical vertebra; however, after treatment of dental occlusion, it was recovered to the normal pattern.




Figure47
Teeth were revealed as the major cause of distorted posture and spine
Mandibular joint, Sacroiliac jointAbnormal dental occlusion is associated with changes of the systemic postures including distortion of sacrum bone, curvature of vertebral column, differences in lengths of bilateral legs and heights of bilateral shoulder, lateral transition of the central axis and gravity center.



Figure48
Classification of distorted postures
Which type of the postures do you have?The distorted patterns can be collated by the following factors such as back-and-forth distortion, lateral distortion and rotation around the body axis.

2008-06-23

Section 2-1. Sounds of teeth resonate not only with brain but also with the whole body

During our investigation of the correlation between teeth and health from the view point of salivary secretion in vivid elderly persons, it was clarified that teeth were closely correlated with autonomic nervous system functions, whereby the central concept “Hazo (Teeth-organ)”theory was established as a new paradigm. However, another question was raised in the initial stage of our study, “the relationship between dental functions and the persisting period of time under standing on one foot with both eyes closed” still remained unknown.
The persisting period of time under standing on one foot with both eyes closed is a simple test in which balance function of the body without any help of visual power is investigated. As the results, good biting with healthy teeth was found to be associated with favorable balance function. Simple comparison between the residual number of teeth and the persisting period of time under standing on one foot with both eyes closed failed to reveal any correlation like those in the salivary secretion.When these data became available, I could not understand why dental functions were correlated with balance activity but it is quite reasonable because conventional dental common sense (Teeth are only a part of digestive organs and responsible only for chewing functions.) could not permit us to imagine the relationship with the balance activity. There was a possibility to overlook this key point because this finding was too unbelievable. If the balance activity without any help of visual activity is recognized as the information treatment by brain, the balance activity is regarded as the results of higher level control in the brain stem including righting reflex based on labyrinth system and proprioceptive sensation, muscular tonicity and cooperation with anti-gravity muscles. These data preceded the word coinage of “Hazo (Teeth-organ)”, besides detailed data suggestive of the relationship between teeth and systemic functions being not available at that time. “Why are these data obtained” this question lasted for a long time after that.
When the information emitting features of teeth to brain based on the “Hazo” concept was obviously proved, these facts gave me a valuable hint and I really wanted to prove this correctness in a clinical field. Then, I tried to prepare the artificial teeth carefully to satisfy the suitable dental occlusion for a vivid elderly person who could not stand up on his foot. Immediately after implantation of the beautifully fitted artificial teeth, this elderly person who previously could not stand up walked to my surprise.
When I experienced this case, I murmured “The keyword to connect teeth with the persisting period of time under standing on one foot might be the dental occlusion”. Now time comes to give the final answer to the long-lasting pending question.
If there is a correlation between dental occlusion and the balance functions, what is the mechanism for such a remote connection? Through our study on teeth and saliva, involvement of autonomic nervous functions as a “Hazo” feature was disclosed; however, this could not stand for the relevant mechanism. It seemed to me that there would be any other “Hazo” functions.By the way, during pursuing the relationship between teeth and autonomic nerve, I showed that teeth provided sounds but there is a possibility that in terms of maintenance of posture, each tooth exerts its own sound. Accordingly, I changed the height of each tooth a bit and then, I monitored changes of the subject posture. As the results, I observed significant changes which could be compared to the dancing posture. Please look at Figure 37.
When the height of the medial incisor is elevated a little, the subject face turns upward and the head seems to be pulled down to the backward. In addition, the body weight is supported on the inside and the subject stands with a pigeon-toed posture. As the next step, the height of the side incisor is higher a bit (Figure 38), the face is similarly pulled upward, the body is leaned backward and the body weight is supported by the heels with the toe being elevated. As the results, the breast is projected. As the next step, the height of the canine is elevated (Figure 39) and the upper half of the body is pulled backward, with the knees being projected, the abdomen being also projected forwards and the low back being bent backward, indicating that excessive load is placed on the low back.

However, if the first bicuspid becomes a little higher (Figure 40), the different response from those in the front teeth is observed. No bent of the posture is found but the body itself is twisted from the knee toward the right side which is opposite to the bitten side. The central axis is straight. The subject feels that the head axis is also straight.

When the second bicuspid becomes higher (Figure 41), quite a different change occurs. The shoulder on the bitten side becomes lowered while the head is leaned to the left. If we investigate the pattern of the body weight on the foot, it is observed that the body weight is on the whole foot sole unlike the pattern found after stimulation of other teeth. Next comes the elevation of the first molar teeth (Figure 42), the abdomen is projected forward, the knee being also projected forward. As the result, the back-ward leaned posture is observed, indicating loading on the low back. When the second molar teeth become higher (Figure 43), the left shoulder is pulled backward unlike those in the first molar teeth and the body is twisted to the left side which is the same side with the elevated height of the teeth, and the body is leaned.
The central line of the body is leaned to the left side unlike those in the first bicuspid. If the height of the third molar teeth is increased, the subject feels as if the whole body is pulled backward (Figure 44).
Like these examples, investigation of the body posture following changes of the heights of each tooth showed that dental occlusion is associated with the body posture closely. The second bicuspid teeth (the fifth position from the front part) correspond to the most behind second deciduous molar teeth in children. These teeth play a role as the dynamic center and can be designated as the supporting point. Whenever we talk about the heights of bilateral occlusion, the height of this second bicuspid tooth is used as the standard. Unless this tooth height becomes irregular, we cannot obtain appropriate occlusion balance even if treatments are given to other front teeth or back teeth, resulting in morbidity of various symptoms. For example, in case of lower height of this tooth, there might occur pains from blade bone to shoulder, pains and numbness from shoulder to arms via outer side of arms, or numbness of the middle finger and pains due to inflammation of the tendon sheath of thumb, as well as muscle weakness. As regards changes in lower half of the body, pains from low back to knee via thigh sometimes occur. However, the subject could not recognize that the heights of these teeth are too low.
In the previous Section, it was explained that there are the sympathetic nerve triangle in the front part and the parasympathetic nerve triangle. It is very interesting to note that the supporting point of the dynamic balance between the autonomic nerve balance and the occlusion are shared. When the height of this second bicuspid is adjusted to be suitable for occlusion, the subjects sometimes say “I feel exciting”; furthermore, the subject referred to his experience to have felt not only physical changes including pains and numb feeling but also sensation of some changes in biological mechanism involved in secretion of intrabrain hormone.
In any events, it seems to us that teeth exert not only autonomic nerve functions but also quite different information emission functions to brain and the whole body. And, these functions are unique in that they are different by respective teeth. It would appear likely that they contributed to changes in balance functions in vivid elderly persons as the background mechanisms but a large-scaled “Hazo (Teeth-organ)” mechanism seems to exist. Through investigating the relationship between teeth and the postures, we wish to study further on these points to clarify another “Hazo” function.



Figure37
Influences of the medial incisor on the posture
We investigated influences of teeth on the posture by experimentally elevating teeth a little bit. Left side teeth were subjected to investi-gation. When the height of the front medial incisor was elevated, the subject face turned upward and the head was pulled down to the backward. As the result, the body weight was supported on the inside and the subject stood with a pigeon-toed posture.



Figure38
Influences of the side incisor on the posture
As the result, the face was similarly pulled upward and the body was leaned backward, with the toe being elevated. The breast was projected forward with the excessive load being placed on the low back.



Figure39
Influences of canine on the posture
The upper half of the body was pulled backward, with the knees being projected; simultaneously, the abdomen was also projected forwards and the low back was bent backward, indicating that excessive load was placed on the low back.



Figure40
Influences of first bicuspid on the posture
The body itself was twisted from the knee toward the right side. The central axis was felt to be straight.



Figure41
Influences of second bicuspid on the posture
The left shoulder was lowered while the head was leaned to the left.



Figure42
Influences of first molar on the posture
The abdomen was projected forward, the knee being also projected forward. As the result, the back-ward leaned posture was observed, indicating loading on the low back.



Figure43
Influences of second molar on the posture
The left shoulder seemed to be pulled backward and the body was twisted to the left side.



Figure44
Influences of third molar on the posture
The whole body seemed to be pulled backwards.

2008-06-20

Section 1-7. Summary of autonomic nervous system of teeth

Now shall we collate the autonomic nerve functions of teeth which are considered to be one of the “Hazo (Teeth-organ)” functions?

1.Teeth emit information to autonomic nervous system.

2.Individual tooth exerts different autonomic nerve stimulation effect by each kind of tooth.

3.In particular, maxillary canine tooth, first bicuspid, submaxillary first bicuspid, third molar tooth show sympathetic nerve-like functions while maxillary first molar, submaxillary first, second molar teeth exhibit parasympathetic nerve-like functions.

4.The functions shown by maxillary and submaxillary second bicuspid and maxillary second molar teeth are unknown but there is a possibility to emit coordinating information such as reducing blood pressure and salivary secretion amount.

5.Teeth provide collaborative functions bilaterally. Once unilateral teeth are lost, information emitting function is greatly damaged.

6.Antagonistic information emitting ability by kinds of teeth might be associated with systemic homeostasis maintenance functions.
Figure 36 illustrates autonomic nervous functions by respective teeth.

The maxillary canine, first bicuspid and submaxillary first bicuspid tooth comprise the front triangle characteristic of stimulating sympathetic nerve system while the maxillary first molar, submaxillary first molar and second molar teeth comprise the posterior triangle characteristic of stimulating parasympathetic nerve system. Among these teeth, maxillary and submaxillary second bicuspid teeth and maxillary second molar teeth are located to coordinate the above-stated autonomic nerve stimulating teeth; furthermore, the submaxillary canine and third molar teeth supplement these functions.
Now that these “Hazo (Teeth-organ)” functions are proved by the study on their autonomic nerve functions, we anticipate that there might be other hidden functions in addition to autonomic nervous systems. One of them is the presence of “Hazo” functions which are evident from the view point of teeth occlusion. Shall we investigate them in the next Section in more details?
Upon closing this Section, I wish to verify the “Hazo” effects of teeth by referring to the testimony of a certain patient.

Before receiving dental treatments, some symptoms were perceived including
difficulty of bending my wrist and pains upon bending the wrist.
Gradually, unhealthy conditions are created. One day, I could not raise my right arm and I could not turn round my arm; subsequently, conditions were aggravated gradually. Low back pain was accompanied by pains or numb feeling of right hip joint, knee and ankle region. I rushed into a near-by orthopedic clinic.I could not sleep well at night. While lying down on my bed, I awoke and it was difficult to get up in the next morning. Some friends of mine told me “You are suffering from postmenopausal symptoms” and I agreed to them in a sense. Right shoulder stiffness was so serious that hard lump was palpable from the hind part of head to the neck. I also felt pains in the bottom of my right eye ball and I could not tolerate keeping my eye open. However, when I closed my eye, I suffered from dizziness. I was easily fatigued and I felt down on my bed around 3 P.M. because of my light-headedness. I was mentally depressed in the latter half of the last year.After treatment. This February, I underwent dental treatment. I could not forget the subsequent changes after treatment of abnormal occlusion and removal of metal implant. On that day, I had no pains on my low back while I was standing in a train for about 30 minutes. My right shoulder was felt light. Fatigue disappeared surprisingly. I had a regular bowel movement and intractable constipation disappeared. My body stiffness was eliminated. I could get up smoothly in the morning and I was so surprised to find no fatigued feeling. Low back pain was eliminated.
After dental treatment (improvement of abnormal occlusion and removal of metal implant), I shouted “I really recognized real healthy conditions now”.
Unbelievable alleviation was felt on these days. I really thank you, Dr. Muratsu, for your kindness.

(42-year-old woman, Fukuoka)



The following is the letter which was sent 2 years later from this woman.

When I revisited Dr. Muratsu’s clinic to receive check & care, I recognized that in the past one year, I had no experiences of impaired health conditions. Such a serious low back pain, stiff shoulder and the like completely disappeared. In particular, pigmented spot on my cheek was gradually disappeared. Its color is faded away. I was expecting complete elimination.After the initial treatment, symptoms were dramatically alleviated but almost one year was required to attain the stable conditions. Whenever any symptoms occurred, Dr. Muratsu examined them and
he kindly encouraged me. In the second year, my physical conditions were continuously improved.About 2 months before the present check & care, I perceived a little bit alteration of dental occlusion. Left jaw was unusual and pains were felt when I chewed food with left side teeth.
Gradually, I felt neck pain and stiff shoulder. Accordingly, I revisited Dr. Muratsu’s clinic this time. He told me “The supernatural “Qi (Special spirit according to the Oriental philosophy) has not operated” and treated me.
After treatment, upper and lower extremities became wormer. I was so much
surprised and recognized importance of teeth.





Figure 36
Distribution patterns of autonomic nervous functions by individual teeth

2008-06-18

Section 1-6. Construction of teeth as the bilaterally-symmetric structure

Our teeth are bilaterally arranged symmetrically in our mouth. Is there any significance of such symmetrical locations of teeth? Are there any functional meanings related to “Hazo (Teeth-organ) theory” hidden behind them? Concerning physical chewing ability, extraction of teeth only from one side theoretically results in reduction of their functions by 50 %; however, how is the influence in terms of internal information emitting functions associated with the organ theory? We are wondering whether only half of the functions are reduced in similar manners as those of chewing functions, or any other influences occur. These are also interesting points for us to note.
Let’s conduct one experiment. For example, we shall anesthetize one submaxillary back tooth on the right side and ask the subject to bite something with this anesthetized tooth. Naturally, the subject cannot recognize biting something because the right jaw is paralyzed and accordingly, salivary secretion is not changed. Unless anesthetized, chewing something with back teeth causes secretion of saliva. As the next experiment, the left jaw is anesthetized and the subject is asked to bite something with the opposite side teeth (right side). The right side teeth (not anesthetized side) perceive chewing whereas the left side jaw is paralyzed. What happens? Salivary secretion is prohibited. Even if the opposite side is anesthetized, chewing with intact teeth does not induce salivary secretion. Namely, our brains distinguish difference of both side teeth and such difference is well treated. For example, in case of a certain marathon runner running up the steep slope while gritting his teeth, salivary secretion does not occur. This is because the signals transmitted from bilateral teeth are treated in brain where it is recognized that “The present signal is not attributed to stimulation due to chewing something”. As the results, unnecessary salivary secretion is not caused.
Taking into account the function of “Hazo (Teeth-organ)”, extraction of one tooth indicates a possibility to provide a great damage on a package of teeth. In more details, bilateral teeth play a combined role. For example, when we walk on foot, a single leg cannot achieve smooth gait and a pair of legs permits walking and running. Similarly, bilateral teeth cooperate each other to achieve their responsibilities.
Figure 18 in the previous Section 3 suggests such a bilateral teeth function. Namely, the reduction ratio of functions in the cases with all the teeth being lost is equivalent to those in the cases with unilateral loss of teeth. Shall we verify this fact by referring to blood pressure? Please look at Figure35.In this figure, the minimum blood pressure is compared in the following cases (0) no loss of maxillary first bicuspid characteristic of sympathetic nerve features, (1) one loss, and (2) two losses. As is obvious from Figure 35, no difference was observed in the diastolic blood pressure between one loss and two losses. On the other hand, in the case with two complete teeth, the diastolic blood pressure was significantly higher than those in the above two cases with P<0.001.



figure35
Pair effects of teeth according to blood pressure changes
In this graph, the number of lost teeth [0] denotes that both of these two teeth remain; [1] means that one tooth is extracted while [2] denotes that both of these teeth are lost. If one tooth out of the paired teeth is lost, the similar changes in blood pressure are observed like those after lost of two teeth.

2008-06-16

Section 1-5. Dynamic homeostasis maintenance effects of teeth which are observed in salivary secretion. Teeth hustled!

Please look at Figure 33. Persons with both back teeth characteristic of parasympathetic nerve stimulating features and front teeth such as canine and bicuspid characterized with sympathetic nerve stimulating features show normal secretion amount of saliva (secretion volume) and normal quality of saliva (protein concentrations); however, if both of them are lost, both amount and quality of saliva are decreased down to almost half of the normal levels. What happens if all the back teeth are lost but all canine teeth and bicuspid teeth still remain? The investigation results demonstrated that the secretion amount of saliva was decreased to almost the half due to loss of all the back teeth but the quality of saliva showed higher values than those in persons with all the teeth remaining; as the result, the total amount of protein in saliva was maintained at the same levels in persons with complete set of back teeth and front teeth. In other words, when the saliva amount is decreased by loss of back teeth, functions of front teeth are augmented to compensate such a loss resulting in producing higher protein concentrations. Eventually, there is a possibility that the total protein amount might revert to the similar levels. There is observed a homeostasis maintaining effect, suggesting that this is a timely and exquisite action. In this study, we investigated only the total protein amount but we did not perform any study on time-course changes of enzyme amounts and bio-active materials which were contained therein.
However, as explained in the results of the animal experiments shown in the Section 3 (4) of the previous Chapter, alterations of chewing stimulation by teeth were associated with kinds of proteins which were synthesized within salivary glands. According to these facts, it is anticipated that in parallel with changes of chewing stimulation due to loss of teeth, not only secretion amount of saliva and protein concentrations but also qualitative changes in salivary protein contents occur also in humans to maintain the homeostasis of the vital functions. Teeth work well for such a purpose.
Nevertheless, once canine and bicuspid teeth are finally lost, the said function to maintain homeostasis cannot act for this purpose. The quantity and quality as well as the total amount of proteins are extremely lowered. This response suggests that teeth exhibit not only chewing function as a part of digestive organs but also emission of the internal information. Eventually, they are involved in maintaining homeostasis of highly sophisticated systemic functions such as mutual antagonism or compensation. Really, teeth are proved to be our organs.
Shall we investigate the universality of this “Hazo (Teeth-organ) theory” by studying consistency of the data concerning the autonomic nervous functions of teeth? As shown in Figure 34, when comparative investigations were performed on the salivary protein concentrations between the persons with maxillary canine teeth and submaxillary first bicuspid teeth characteristic of exhibiting sympathetic nerve stimulating effects, and the persons without corresponding teeth, the protein concentrations in saliva in the latter persons were decreased to more than half of those in the former persons.
On the other hand, similar investigations were conducted on influences of these teeth on blood pressures whereby the same autonomic nervous effects as observed in the salivary secretion were evidenced. These facts demonstrate that presence of these teeth contributed to maintenance of higher blood pressure than those in the persons without these teeth. Thus, the investigations on quite independent two systemic factors showed the same outcomes concerning autonomic nerve functions of teeth, and therefore, these results provide obvious evidence indicating that teeth exhibit both the autonomic nervous functions and the organ features.




Figure 33
Homeostasis maintenance effect by salivary secretion functions of teeth
The maxillary first and second molar teeth strongly affect salivary secretion amount while the maxillary canine and submaxillary first bicuspid remarkably provide influences on salivary protein concentration. When all of these four teeth remain, both quantity (secretion amount) and quality (protein concentration) as well as the total protein amount are found normal; however, if some of them are lost, the salivary secretion ability is reduced. Nevertheless, even if maxillary first and second molar teeth are completely lost, presence of intact canine and first bicuspid, as shown in the second frame from the right, is responsible for maintenance of protein concentrations or slightly higher level, together with maintenance of the almost similar level of total protein amount as those in the normal situations. This indicates the homeostasis maintenance function. Incidentally, if teeth are gradually lost reaching removal of both canine and first bicuspid, the homeostasis maintenance function seems collapsed, and the total protein amount is sharply decreased to less than half of the normal level.



Figure 34
Consistency of the salivary secretion of teeth with influences on blood pressure
In this figure, the number of lost teeth [0] denotes that all the teeth remain intact while [4] means lost of teeth by 2 pairs, namely 4 teeth being lost. Maxillary canine and submaxillary first bicuspid tend to exert sympathetic nervous influences. Therefore, in case of 2 pairs , or 4 teeth of them being lost, it is postulated that persisting reduction of sympathetic nerve stimulation occur eventually; in fact, the salivary protein concentration characteristic of being strongly affected by sympathetic nerve is decreased. When persisting reduction of sympathetic nerve stimulation occurs, it is anticipated that blood vessels are shrunk to decrease persistently secretion of catecholamine conducive to increase of blood pressure. In reality, both systolic and diastolic blood pressures are reduced in parallel with loss of these relevant teeth.

2008-06-13

Section 1-4. “Hazo “(Teeth-organ theory) and microcosms

You might be familiar to the word “Organs”. However, when organs are positioned from the view point of information systems of our body, it is conceivable that organs control the whole body systems under close cooperation with other organs by both output and input of various information by organs themselves. Please look at Figure 31 (Refer to the colored Figure I) illustrating the conceptual diagram of human body which is compared to the solar system. Once the human body system was regarded as one micro-cosmos moving around brain, teeth were recognized as a trivial presence within the micro-cosmos world corresponding to one satellite attached to a planet indicative of digestive organ. In other words, teeth were designated only as one tool to be used for chewing foods.
On the contrary, however, as shown in Figure 32, teeth were disclosed to exist as one planet (organ) similar to heart, liver and kidney, in the body system; furthermore, teeth play a role as the important information outlet.
Shall we take diabetes mellitus as an example and provide explanation for your better understanding. Diabetes mellitus is caused by inadequate effect of insulin, one of the important hormones. Insulin is secreted from β cells in islet of Langerhans of pancreas. In addition to β cells in islet of Langerhans, there are α and θcells from where various hormones are secreted. After ingestion of foods, the blood with absorbed nutrition and glucose is transferred via portal vein to pancreas and liver.
During this process, glucose in blood is delicately controlled by hormone secreted from islet of Langerhans. For example, insulin secreted from β cells decreases blood glucose levels while glucagons secreted from αcells increases blood glucose levels. Like autonomic nerves including exciting sympathetic nerves and relaxing parasympathetic nerves, two antagonizing factors cooperatively work to keep the physical balance and such a mechanism is called as homeostasis. Both insulin and glucagons in terms of controlling glucose levels work as such a homeostasis.
Once again look at Figure 30 demonstrating the correlation between individual teeth and the blood pressure. Maxillary canine, first bicuspid and submaxillary first bicuspid and third molar tooth elevate the blood pressure. On the other hand, maxillary second molar and submaxillary canine tend to lower the blood pressure. Namely, there are two antagonizing stimulus emitting system. Islet of Langerhans in pancreas is located deep in the abdomen while teeth are hard enough, but both of them are fundamentally the same as their information emitting sources. There is a possibility that back teeth decrease the blood pressure whereas maxillary canine and first bicuspid tooth elevate the blood pressure antagonistically. Although endocrine hormone systems and autonomic nervous system as the messenger conducive to control of the blood pressure via teeth surely exist, it is postulated that salivary gland is also involved in these systems. This is because digestive enzymes such as amylase and parotin as one of the growth hormones as well as endocrine hormone-like bioactive substances including hormones affecting glucose metabolism are produced and secreted from salivary gland into blood. The following data regarding maintenance of homeostasis permit us to anticipate presence of dynamic organ-like effects of teeth with salivary gland being involved therein.



Figure 31
Previous wrong conceptual diagram of teeth on human body micro-cosmos
When the human body system is regarded as the micro-cosmos, teeth were wrongly considered as one satellite for the planet which did not directly affect the whole body (life) (Please refer to Figure I).



Figure 32
New conceptual diagram of teeth on human body micro-cosmos
Now that we recognize “Teeth are our organs.” and take into consideration the information emission ability of teeth directly to the whole body in addition to their chewing ability.

2008-06-11

Section 1-3. Dental heliocentric theory

Now looking back upon my previous days, I was firmly convinced of the existing conventional medical paradigm insisting “Teeth are one of digestive organs.” This firm image led me to a chaos in which I could not explain the obtained results with more advance of my study. During such confusion, I recognized suddenly that our evidence might be compared to a discovery about the heliocentric system proposed by Copernicus. In the 16th century when the geocentric theory prevailed in the world. However, Copernicus, resisting to be swept away by the common stereotype based on the common sense, piled up the data obtained by astronomical observations, whereby he faced discrepancy between these observation results and the paradigm derived from the geocentric theory. Eventually, the following question occurred to him, “Is the earth moving around the sun, instead of the sun moving around the earth?” and he carefully analyzed the obtained data about the astronomical movement. To his surprise, all the findings could be beautifully consistent without any discrepancy and then, the heliocentric system was accepted and propagated throughout the world.
The discovery of the “Teeth-organ theory” is a notification which topples down the conventional paradigm like the heliocentric theory. Yes, “Teeth are our organs”. This can be depicted as one word, “Hazo (Teeth-organ Theory)”. When I obtained this key word indicating a new dental paradigm, my “Hazo revolution” newly started. When I murmured this key word “Teeth are our organs”, a dark labyrinth was found to be an illusion and I found myself standing at a top of the glorious summit from where I could command a vast plane.

2008-06-09

Section 1-2. Teeth are our organs

I hurriedly wrote this article to Chapter 2 in one breath. In my research activities, whenever I opened a door, another door was awaiting me and I dashed with excitement on new questions. Any doors could not be opened easily. For example, the multi-variable analysis on saliva and blood pressure took me about 1 year during which I visited a large-scale computer center located in the campus of Kyushu University almost every day. It seemed to me that this research to scientifically prove the correlation between teeth and systemic functions would appear like an uncultivated dark jungle whereby I could not proceed easily. However, I stepped forward steadily.
When I stepped forward in a deep jungle, most of the observed facts could not be explained by the currently available medical paradigm but were conflicting mutually. How does the so-far existing definition about teeth “Functions of teeth exist on chewing foods as a part of digestive organs” permit us to explain the facts which were discovered in this jungle, such as “the correlation between teeth and salivary secretion” and “relationship between teeth and blood pressure”? Furthermore, the discovered facts tell us that individual tooth is responsible for the emitting function of the information to the brain individually. One of the followings might be wrong, either the existing medical paradigm that we were taught in the medical education curriculum, or the facts I discovered during my research. However, my research started from a simple question “Are teeth really necessary for maintenance of human health?” but not from an eye-catching research objective such as “To clarify the correlation between teeth and systemic functions”. While respecting each fact and recognizing my own limitation, I asked for advices and recommendations of specialists of other fields than dental research. During the research, I scientifically proved respective evidences and I reached this stage. Accordingly, there is no possibility that the research findings so far explained in this book would be mistakes.
As a natural consequence, the medical paradigm which was taught in my university days turns out to be wrong. If so, then another question comes to our minds, “What are teeth on the earth?”. I was quite at a loss at this stage. What’s worse, the existing medical paradigm does not work at all in this labyrinth although such a paradigm was used as a compass or the reliable chart. What shall I do? Another question came to my mind.
This puzzle was unexpectedly solved. One day, I had a chattering with an internist with whom I got acquainted in a hotel lounge-bar in front of Hakata Station in Fukuoka city. At that occasion, fortunately I had a slide shown in Figure 30 in my bag. Since I was always asking to myself “What are teeth?” in those days, I showed the slide to him just as a topic of conversation, while saying “I have some interesting data regarding teeth”. After looking the slide for a moment, he murmured a word “Oh, teeth are our organs”.
“-------!“
At that occasion, something sparkled in my head.“Oh, yes. Teeth are our organs!” I shouted with my fingers being closed into a fist.

2008-06-06

Section 1-1. Each tooth exhibits different influences on blood pressure

Based on the close correlation between salivary secretion and teeth, we advanced the hypothesis that teeth are involved in autonomic nervous system functions. Subsequently, we clarified the relationship between “Blood pressure” as one of the systemic factors and teeth whereby we could sustain this hypothesis. In the previous Chapter, such an explanation was made but there still remains another theme to be confirmed. As briefly described in the articles related to salivary secretion functions, there is another issue whether any contrary stimulating system corresponding to sympathetic and parasympathetic nerves in the autonomic nervous system might exist or not. In terms of blood pressures, there seems to be contrary effects in teeth based on the equation model obtained from determination of blood pressures; however, we wish to investigate part-specific influences according to kinds of teeth from the view point of the relationship between teeth and blood pressures. Are there any antagonizing effects or harmony in the blood pressures according to kinds of teeth as was observed in investigation of salivary secretion?
Figure 30 illustrates the correlation between kinds of teeth and blood pressures which were calculated during the multi-variable analysis on the blood pressures depicted in the previous chapter. This figure shows the fact that each tooth exhibits individual influences on blood pressures to control them. In the submaxillary part, first bicuspid and third molar contribute to elevation of blood pressures. The canine tooth tends to lower the blood pressure instead. The medial incisor, lateral incisor, second bicuspid and first and second molar teeth seem to exhibit neutral effects. On the contrary in the maxillary part, canine and the first bicuspid have blood pressure increasing effects whereas on the contrary, the second molar seems to lower the blood pressure. In the similar manners as those in the submaxillary part, medial incisor, lateral incisor, the second bicuspid and the first molar teeth tend to exhibit neutral actions. The data lines for the teeth, the maximum blood pressure and the minimum blood pressure in Figure 30 were calculated independently; however, beautiful coincidence of the trend according to kinds of teeth indicates high reliabilities of the obtained results. As was the same with the results obtained in salivary secretion functions, blood pressures are affected by individual tooth differently. Furthermore, such effects were found to be contrary or antagonistic as was found in the autonomic nerve functions.



Figure 30
Correlation between teeth by their kinds and blood pressure
These graphs show the correlation between individual submaxillary teeth and blood pressures which were calculated during the multi-variable analysis. The figures from 1 to 8 shown on the horizontal axis denote, (1) medial incisor, (2) lateral incisor, (3) canine, (4) first bicuspid, (5) second bicuspid, (6) first molar, (7) second molar, and (8) third molar. On the vertical axis, the upper column shows the systolic blood pressures, with the lower column for the diastolic blood pressures. Furthermore, please understand the followings while reading these graphs. There is a reference line at the point of 0. The blood pressures below this line mean that the blood pressure shall be lowered by stimulation of teeth whereas on the contrary, the blood pressures above this line indicate that the blood pressure shall be increased by stimulation of teeth. This suggests that individual tooth exerts different influences on blood pressures; as explained in +,-signs for teeth variables in the model equation, influences by individual tooth are not homogeneous but they change blood pressures independently. In terms of submaxillary teeth, both submaxillary first bicuspid (4) and third molar (8) tend to elevate blood pressures while the canine (3) lowers blood pressures. In the similar manners, please look at the maxillary teeth. It would appear likely that both canine and first bicuspid increase blood pressures. On the contrary, second molar seems to decrease the systolic blood pressure. In these graphs, the data lines for teeth as well as systolic and diastolic blood pressures were separately calculated; however, beautiful consistency in trends of teeth provide us with confidence of good reliability.

2008-06-04

Section 4-3. Proof by multi-variable analysis. Teeth actually affect blood pressure

Decision of the equation model concerning blood pressures was conducted by the systemic factors as shown in Figure 9 as was the same with salivary secretion. Figures 25 and 26 show both systemic and diastolic blood pressures in the subjects with more than 13 teeth; however, the risk rates (P value) of their errors were 0.0001 indicative of a highly reliable equation model. In both cases, 7 factors were selected as the descriptive variables but it was proved that teeth played an important role in both systolic and diastolic blood pressures.
The teeth selected as influential teeth were submaxillary first bicuspid and third molar tooth, maxillary canine and second bicuspid, maxillary first bicuspid, first and second molar teeth. To be noted is the fact that “―” signal in the model equation indicates the following general trend such as teeth elevating blood pressure but maxillary second bicuspid and second molar tooth lowering blood pressure. These interesting findings led us to recognize the key notion “Teeth are our organs”; however, details shall be described later. It is noteworthy that the third molar tooth (wisdom tooth) is deeply involved in elevation of blood pressure. According to the common sense in the dental field, the wisdom tooth is useless but on the contrary, it seems to us that this tooth might play an important role in maintaining vitality and vigor of humans. In hypertensive patients, there is a possibility that continuous and too strong stimulation is given to the teeth conducive to increasing blood pressure such as the wisdom tooth, maxillary first bicuspid, first molar and canine as well as submaxillary first bicuspid and second bicuspid, or weaker stimulation is given to maxillary second molar and second bicuspid which lower blood pressure. In hypotensive patients, we can anticipate that hypotension is induced by the contrary mechanism related to the above-stated teeth. This is a key theme related to the organic features of teeth, and accordingly, this shall be referred to below in details. This would appear likely to imply extremely important issues.
Figures 27 and 28 show the equation model regarding the maximum and the minimum blood pressures in the cases with less than 15 teeth.
In terms of the minimum blood pressure, we obtained 0.9 as the multiple correlation coefficient, 0.81 as the contribution ratio and 0.0002 as the risk ratio P, all of which suggests extremely high reliability, indicating that teeth play an important role in the diastolic blood pressure. The selected teeth were maxillary medial incisor and submaxillary canine tooth. These teeth seem contributory to decrease of blood pressure.
As briefed above, the order of teeth to be lost is maxillary and submaxillary molar, bicuspid, maxillary canine and front teeth, and finally submaxillary canine and front teeth, in this loosing order. This means that the subjects with less than 15 teeth hardly have molar teeth. In the equation model concerning the maximum blood pressure, the contributory ratio indicative of power of explanation is 0.42; this means that if the complete explanation by this model is regarded as 100, only 42% can be explained. This indicates that in addition to the stipulated explanatory variables, there might exist more influential other factors. In any events, when the remaining teeth become less in number, the influential power of teeth on the maximum blood pressure is negligible. This phenomenon is attributed to absence of the teeth influential to the blood pressure due to extraction.
The results obtained by the above-stated multi-variable analysis verified that teeth provide influences on the blood pressure without any influences of the systemic background factors and furthermore, the influences of teeth are so decisive to control the blood pressure in comparison with other systemic factors. This is an epoch-making discovery because the total population under treatment of hypertension is estimated to amount to more than 10 million in Japan. If candidates with border-line hypertension and latent hypertension are included, more than 2 to 3-fold population, namely approximately 30 % of Japanese people are suffering from hypertension. As is well known, hypertension is classified into secondary hypertension of which causes are clarified and essential hypertension characteristic of unknown causes whereas more than 90 % of the patients belongs to the latter essential hypertension. Despite of remarkable progress of medical researches, actual causes of this important disease from which more than 30 million people are suffering have not yet been clarified, suggesting that there might be unexcavated blind points as the research fields. I am now confident that teeth would be responsible for this disease. Shall we review individual testimony from patients which surely convince us of our above-stated confidence?
I was suffering from hypertension for about 10 years. In April 1993, plates were implanted at Muratsu Clinic to correct irregular bites. As the results, the diastolic blood pressure was lowered to 80s mmHg, with the systolic blood pressure decreasing to 130s mmHg. Subsequently, my blood pressures have been continuously stable. (64 years old, male, Fukuoka)
This patient had received treatment of hypertension in the Kyushu University Detached Hospital. Judging from his age, it was very rare to have his own teeth under a relatively complete condition. As shown in his memo, he was diagnosed to have hypertension about 10 years ago and he took the prescribed anti-hypertensive agents; however, his hypertension was not improved, resulting in continuously persisting. However, immediately after treatment of abnormal occlusion, efficacy was promptly observed to show blood pressure decrease down to the normal healthy levels (Figure 29). You can find sudden decrease of blood pressure immediately after commencement of occlusion treatment from this figure.
This fact corroborates that teeth are responsible for onset of persisting hypertension. These data had been independently stored as the record of his blood pressures in a hospital where he received medications; however, he kindly brought these data to us because he was so pleased of improvement of hypertension by our dental treatment. Before and after out dental treatment, no alterations of prescribed drugs including combined use with other drugs were made. He is still continuing his preventive cares at our KOS clinic but no relapse of hypertension is observed.
Next witness comes from a female patient who showed improvement of hypotension and systemic health conditions following recovery of dental health. Coupled with testimony of her son, this letter surely makes you recognize the fact that teeth provide influences not only blood pressure, autonomic nerve but also systemic conditions.

Since my childhood, I was always suffering from some diseases. When I
was 19 years old, I suffered from Basedow's disease and I felt some anxiety;
furthermore, I was so nervous about health and whenever tiny abnormality was
perceived, I became depressed. Under such conditions, I got married and
gave birth to a child. Although I was susceptible to diseases, I kept
working very hard. Under such situations, I was introduced by my
elder brother to Dr. Muratsu and I received the dental treatment and gradually,
I recognized that my health was recovered. Very tiny improvements occurred
including stepping up high stairways, easily walking in a bustled area and
disappearance of stiff shoulder and eye ball pains.
Significant changes were found in blood pressures. Before treatments,
I was suffering from hypotension with the systolic blood pressure of 87 mmHg and
as the maximum up to 95 mmHg even during pregnancy. I was not so nervous
about lowered blood pressures because I had been accustomed to hypotension but
after completion of the dental treatment, I happened to know elevation of the
systolic blood pressure to 110~120 mmHg. I could not find out any other
causes except treatment of teeth. I was surprised at this change because I
had considered that hypotension could not be cured.
My son also received treatment of rhinitis. He always sniffled but
immediately after dental treatment, he appeared without any sniffling from Dr.
Muratsu’s office. He had had very nervous characters previously but
recently, this feature was improved. When he became a fourth grade
elementary school child, he entered an extracurricular club. Dr. Muratsu,
I really appreciate your kind treatment so that all of our family members are
confident about our health.
(41-year-old woman, Kumamoto)


This patient had a partial irregular occlusion in the front part which should be treated by means of prosthetic correction methods.


Figure 25
Equation model of systolic blood pressure (1)
(Current No. of teeth: ≧13 teeth)
------------------------------------------------------
Systolic blood pressure = 157
+13.1 X Submaxillary third molar
+16.3 X Maxillary first bicuspid
+5.1 X Maxillary first molar
-10.8 X Maxillary second molar
-0.44 X pulse rate-21.6 X Albumin/globulin ratio
+2.6 X Ca amount
------------------------------------------------------
Multiple correlation coefficient=0.8
Contribution ratio =0.65
P value<0.0001
This is the equation model for systolic blood pressure (General linear multiple regression model) in the cases with more than 13 teeth as the current residual number of teeth. The multiple correlation coefficient indicating the degree of correlation was 0.8, with the contribution ratio indicative of power of explanation being 0.65, and the p value indicative of the statistical significance being 0.0001. All of them suggest that the scientific credibility is extremely high. The fact that the dental factors are selected as the explanatory variables on the right-hand side means that teeth are involved in systolic blood pressure. Particularly, maxillary first bicuspid, first molar, second molar and submaxillary wisdom tooth seem to be implicated.


Figure 26
Equation model of diastolic blood pressure (1)
(Current No. of teeth: ≧13 teeth)
------------------------------------------------------
Diastolic blood pressure = 14.7
+7.96 X Submaxillary first bicuspid
+4.99 X Submaxillary third molar
+7.95 X Maxillary canine
-4.03 X Maxillary second bicuspid
+0.81 X Age
-0.01 X Noradrenaline level
+0.11 X HDL cholesterol level
(Medical items are obtained from the serum.)
------------------------------------------------------
Multiple correlation coefficient=0.89
Contribution ratio =0.79
P value<0.0001
This is the equation model for systolic blood pressure in the cases with more than 13 teeth as the current residual number of teeth. The multiple correlation coefficient was 0.89, with the contribution ratio being 0.79, and the p value being as small as 0.0001. All of them suggest that the scientific credibility is extremely high. The fact that the dental factors are selected as the explanatory variables on the right-hand side means that teeth are involved in diastolic blood pressure. Particularly, maxillary canine, second bicuspid, submaxillary bicuspid and wisdom tooth seem to be deeply implicated.


Figure 27
Equation model of systolic blood pressure (2)
(0<Current No. of teeth: <15 teeth)
------------------------------------------------------
Systolic blood pressure = -197
+25.2 X Total protein amount
-0.14 X Triglyceride level
+5.1 X Noradrenaline level
+0.003 X Na level
------------------------------------------------------
Multiple correlation coefficient=0.65
Contribution ratio =0.42
P value<0.02
This is the equation model for systolic blood pressure in the cases with less than 15 teeth as the current residual number of teeth. Both the multiple correlation coefficients and the contribution ratio were low, with the p value being high. All of them suggest that this equation model is not credible. In addition, factors related to teeth are not included therein. It postulated that any other factors than the selected factors for this equation might be strongly involved.


Figure 28
Equation model of diastolic blood pressure (2)
(0<Current No. of teeth: <15 teeth)
------------------------------------------------------
Diastolic blood pressure = -13.2
-4.77 X Maxillary medial incisor
-7.77 X Sub maxillary canine
+13.5 X Albumin level
+23.3 X Mg level
-1.45 X Ca level
+0.009 X Noradrenaline level
------------------------------------------------------
Multiple correlation coefficient=0.90
Contribution ratio =0.81
P value<0.0002
This is the equation model for diastolic blood pressure in the cases with less than 15 teeth as the current residual number of teeth. The multiple correlation coefficient was 0.90, with the contribution ratio being 0.81, and the p value being as small as 0.0002. All of them suggest that the scientific credibility is extremely high. It seems that teeth are implicated. In particular, with less residual sub maxillary teeth, stronger influences of maxillary medial incisor and sub maxillary canine are observed.



Figure 29
An example in which treatment of abnormal occlusion alleviated hypertension
Previously, this patient had 152mmHg as the mean systolic blood pressure, 94 mmHg as the diastolic blood pressure, indicating persisting hypertensive situation. Immediately after commencement of occlusion treatment, blood pressures were reduced such as 130 mmHg as systolic blood pressure and 80 mmHg as diastolic blood pressure.

2008-06-02

Section 4-2. Correlation between teeth and blood pressure by the correlation line

Taking into account the fact that the maximum blood pressure (systolic blood pressure) is variable due to influences of various factors, I investigated the correlation between the minimum blood pressure (diastolic blood pressure) and the current number of teeth in accordance with the recommendation by an internist, one of our co-researchers.
Figure 19 shows the results obtained. Simultaneously, a statistician, one of our co-researchers was asked to analyze this result, whereby it was revealed that as shown in the correlation line, there was a folding point around the current number of 13~15 teeth, and the subjects could be assigned into the following three groups; the subjects with more than the number of teeth at the folding point, the subjects with less than the teeth at the folding point and the subjects with no teeth. In these three groups, there was an inflexion point at the border of each classification, suggesting presence of some systematic qualitative difference among these groups.
Figures 20 and 21 provide the distribution of both systolic and diastolic blood pressures in the subjects with more than the number of teeth at the folding point. Both of these figures show positive correlation, indicating that with increase of the current number of teeth, blood pressures become higher.
For your better understanding, the mean blood pressures were compared between the subjects with more than 20 teeth and those with less than 19 teeth. As shown in Figure 22, the subjects with more than 20 teeth scientifically showed higher values both in systolic and diastolic blood pressures.
Next comes the distribution patterns of systolic and diastolic blood pressures in the subjects with less than the teeth number at the folding point (Figures 23 and 24). On the contrary to those beyond the folding point, however, negative correlation was found between the present number of teeth and both systolic and diastolic blood pressures; this indicates that with increased number of the present teeth, blood pressures are decreased. In the subjects without own teeth, the systolic blood pressures were ranging from 95 mmHg to 158 mmHg with the diastolic blood pressures being distributed from 54 mmHg to 83 mmHg.
Thus, the correlational analysis between the current number of teeth and blood pressures disclosed for the first time presence of correlation of teeth with the blood pressures which had not been even suspected. However, blood pressures are susceptible to individual difference factors of the subjects such as ages and systemic background factors including body weight, plasma triglycerides and plasma cholesterol. Accordingly, as is the same with salivary secretion functions, all we have to do is to verify the real influences of teeth on blood pressures following more careful elimination of influences of background factors.
We promptly started studies to confirm the correlation of the two factors between teeth number and blood pressures by using the multi-variable analysis, with the cooperation of internists and statisticians. If teeth as the factor providing obvious influences on blood pressures can be confirmed by multi-variable analysis, we can declare decisive relationships between teeth and autonomic nerves.
In more details, most of the front teeth must be ground to improve the direction of each tooth. At the age of 19 years old, Basedow's disease occurred and since then, she felt fears of her health; however, probably, all of these anxieties stemmed from dental problems. In addition to this case, there are lots of patients whose symptoms related to hypertension or hypotension were alleviated in parallel with recovery of their dental health. As is obvious from these cases, we can say that teeth are clinically associated with blood pressures.



Figure 20
Correlation between the maximum blood pressure (systolic blood pressure) and the current number of teeth (more than 13 teeth) by the correlation line
There was a positive correlation between the residual pattern of teeth and the systolic blood pressure. In other words, loss of teeth results in reducing the blood pressure.



Figure 21
Correlation between the minimum blood pressure (diastolic blood pressure) and the current number of teeth (more than 13 teeth) by the correlation line
There was a positive correlation between the residual pattern of teeth and diastolic blood pressure. In the similar manners as the systolic blood pressure, loss of teeth results in reducing the blood pressure.



Figure 22
Influences of teeth on blood pressures
When the mean blood pressure was investigated in the subjects either with more than 20 teeth as the current residual number or with less than 19 teeth, the subjects with more than 20 teeth left obviously showed higher blood pressure.



Figure 23
Correlation between the maximum blood pressure (systolic blood pressure) and the current number of teeth (≦15 teeth) by the correlation line
There was a negative correlation between the residual pattern of teeth and systolic blood pressure. In other words, loss of teeth results in increasing the blood pressure.



Figure 24
Correlation between the minimum blood pressure (diastolic blood pressure) and the current number of teeth (≦15 teeth) by the correlation line
There was a negative correlation between the residual pattern of teeth and systolic blood pressure. In other words, loss of teeth results in increasing the blood pressure.