Section 1-5. Dynamic homeostasis maintenance effects of teeth which are observed in salivary secretion. Teeth hustled!

Please look at Figure 33. Persons with both back teeth characteristic of parasympathetic nerve stimulating features and front teeth such as canine and bicuspid characterized with sympathetic nerve stimulating features show normal secretion amount of saliva (secretion volume) and normal quality of saliva (protein concentrations); however, if both of them are lost, both amount and quality of saliva are decreased down to almost half of the normal levels. What happens if all the back teeth are lost but all canine teeth and bicuspid teeth still remain? The investigation results demonstrated that the secretion amount of saliva was decreased to almost the half due to loss of all the back teeth but the quality of saliva showed higher values than those in persons with all the teeth remaining; as the result, the total amount of protein in saliva was maintained at the same levels in persons with complete set of back teeth and front teeth. In other words, when the saliva amount is decreased by loss of back teeth, functions of front teeth are augmented to compensate such a loss resulting in producing higher protein concentrations. Eventually, there is a possibility that the total protein amount might revert to the similar levels. There is observed a homeostasis maintaining effect, suggesting that this is a timely and exquisite action. In this study, we investigated only the total protein amount but we did not perform any study on time-course changes of enzyme amounts and bio-active materials which were contained therein.
However, as explained in the results of the animal experiments shown in the Section 3 (4) of the previous Chapter, alterations of chewing stimulation by teeth were associated with kinds of proteins which were synthesized within salivary glands. According to these facts, it is anticipated that in parallel with changes of chewing stimulation due to loss of teeth, not only secretion amount of saliva and protein concentrations but also qualitative changes in salivary protein contents occur also in humans to maintain the homeostasis of the vital functions. Teeth work well for such a purpose.
Nevertheless, once canine and bicuspid teeth are finally lost, the said function to maintain homeostasis cannot act for this purpose. The quantity and quality as well as the total amount of proteins are extremely lowered. This response suggests that teeth exhibit not only chewing function as a part of digestive organs but also emission of the internal information. Eventually, they are involved in maintaining homeostasis of highly sophisticated systemic functions such as mutual antagonism or compensation. Really, teeth are proved to be our organs.
Shall we investigate the universality of this “Hazo (Teeth-organ) theory” by studying consistency of the data concerning the autonomic nervous functions of teeth? As shown in Figure 34, when comparative investigations were performed on the salivary protein concentrations between the persons with maxillary canine teeth and submaxillary first bicuspid teeth characteristic of exhibiting sympathetic nerve stimulating effects, and the persons without corresponding teeth, the protein concentrations in saliva in the latter persons were decreased to more than half of those in the former persons.
On the other hand, similar investigations were conducted on influences of these teeth on blood pressures whereby the same autonomic nervous effects as observed in the salivary secretion were evidenced. These facts demonstrate that presence of these teeth contributed to maintenance of higher blood pressure than those in the persons without these teeth. Thus, the investigations on quite independent two systemic factors showed the same outcomes concerning autonomic nerve functions of teeth, and therefore, these results provide obvious evidence indicating that teeth exhibit both the autonomic nervous functions and the organ features.




Figure 33
Homeostasis maintenance effect by salivary secretion functions of teeth
The maxillary first and second molar teeth strongly affect salivary secretion amount while the maxillary canine and submaxillary first bicuspid remarkably provide influences on salivary protein concentration. When all of these four teeth remain, both quantity (secretion amount) and quality (protein concentration) as well as the total protein amount are found normal; however, if some of them are lost, the salivary secretion ability is reduced. Nevertheless, even if maxillary first and second molar teeth are completely lost, presence of intact canine and first bicuspid, as shown in the second frame from the right, is responsible for maintenance of protein concentrations or slightly higher level, together with maintenance of the almost similar level of total protein amount as those in the normal situations. This indicates the homeostasis maintenance function. Incidentally, if teeth are gradually lost reaching removal of both canine and first bicuspid, the homeostasis maintenance function seems collapsed, and the total protein amount is sharply decreased to less than half of the normal level.



Figure 34
Consistency of the salivary secretion of teeth with influences on blood pressure
In this figure, the number of lost teeth [0] denotes that all the teeth remain intact while [4] means lost of teeth by 2 pairs, namely 4 teeth being lost. Maxillary canine and submaxillary first bicuspid tend to exert sympathetic nervous influences. Therefore, in case of 2 pairs , or 4 teeth of them being lost, it is postulated that persisting reduction of sympathetic nerve stimulation occur eventually; in fact, the salivary protein concentration characteristic of being strongly affected by sympathetic nerve is decreased. When persisting reduction of sympathetic nerve stimulation occurs, it is anticipated that blood vessels are shrunk to decrease persistently secretion of catecholamine conducive to increase of blood pressure. In reality, both systolic and diastolic blood pressures are reduced in parallel with loss of these relevant teeth.

Section 1-4. “Hazo “(Teeth-organ theory) and microcosms

You might be familiar to the word “Organs”. However, when organs are positioned from the view point of information systems of our body, it is conceivable that organs control the whole body systems under close cooperation with other organs by both output and input of various information by organs themselves. Please look at Figure 31 (Refer to the colored Figure I) illustrating the conceptual diagram of human body which is compared to the solar system. Once the human body system was regarded as one micro-cosmos moving around brain, teeth were recognized as a trivial presence within the micro-cosmos world corresponding to one satellite attached to a planet indicative of digestive organ. In other words, teeth were designated only as one tool to be used for chewing foods.
On the contrary, however, as shown in Figure 32, teeth were disclosed to exist as one planet (organ) similar to heart, liver and kidney, in the body system; furthermore, teeth play a role as the important information outlet.
Shall we take diabetes mellitus as an example and provide explanation for your better understanding. Diabetes mellitus is caused by inadequate effect of insulin, one of the important hormones. Insulin is secreted from β cells in islet of Langerhans of pancreas. In addition to β cells in islet of Langerhans, there are α and θcells from where various hormones are secreted. After ingestion of foods, the blood with absorbed nutrition and glucose is transferred via portal vein to pancreas and liver.
During this process, glucose in blood is delicately controlled by hormone secreted from islet of Langerhans. For example, insulin secreted from β cells decreases blood glucose levels while glucagons secreted from αcells increases blood glucose levels. Like autonomic nerves including exciting sympathetic nerves and relaxing parasympathetic nerves, two antagonizing factors cooperatively work to keep the physical balance and such a mechanism is called as homeostasis. Both insulin and glucagons in terms of controlling glucose levels work as such a homeostasis.
Once again look at Figure 30 demonstrating the correlation between individual teeth and the blood pressure. Maxillary canine, first bicuspid and submaxillary first bicuspid and third molar tooth elevate the blood pressure. On the other hand, maxillary second molar and submaxillary canine tend to lower the blood pressure. Namely, there are two antagonizing stimulus emitting system. Islet of Langerhans in pancreas is located deep in the abdomen while teeth are hard enough, but both of them are fundamentally the same as their information emitting sources. There is a possibility that back teeth decrease the blood pressure whereas maxillary canine and first bicuspid tooth elevate the blood pressure antagonistically. Although endocrine hormone systems and autonomic nervous system as the messenger conducive to control of the blood pressure via teeth surely exist, it is postulated that salivary gland is also involved in these systems. This is because digestive enzymes such as amylase and parotin as one of the growth hormones as well as endocrine hormone-like bioactive substances including hormones affecting glucose metabolism are produced and secreted from salivary gland into blood. The following data regarding maintenance of homeostasis permit us to anticipate presence of dynamic organ-like effects of teeth with salivary gland being involved therein.



Figure 31
Previous wrong conceptual diagram of teeth on human body micro-cosmos
When the human body system is regarded as the micro-cosmos, teeth were wrongly considered as one satellite for the planet which did not directly affect the whole body (life) (Please refer to Figure I).



Figure 32
New conceptual diagram of teeth on human body micro-cosmos
Now that we recognize “Teeth are our organs.” and take into consideration the information emission ability of teeth directly to the whole body in addition to their chewing ability.

Section 1-3. Dental heliocentric theory

Now looking back upon my previous days, I was firmly convinced of the existing conventional medical paradigm insisting “Teeth are one of digestive organs.” This firm image led me to a chaos in which I could not explain the obtained results with more advance of my study. During such confusion, I recognized suddenly that our evidence might be compared to a discovery about the heliocentric system proposed by Copernicus. In the 16th century when the geocentric theory prevailed in the world. However, Copernicus, resisting to be swept away by the common stereotype based on the common sense, piled up the data obtained by astronomical observations, whereby he faced discrepancy between these observation results and the paradigm derived from the geocentric theory. Eventually, the following question occurred to him, “Is the earth moving around the sun, instead of the sun moving around the earth?” and he carefully analyzed the obtained data about the astronomical movement. To his surprise, all the findings could be beautifully consistent without any discrepancy and then, the heliocentric system was accepted and propagated throughout the world.
The discovery of the “Teeth-organ theory” is a notification which topples down the conventional paradigm like the heliocentric theory. Yes, “Teeth are our organs”. This can be depicted as one word, “Hazo (Teeth-organ Theory)”. When I obtained this key word indicating a new dental paradigm, my “Hazo revolution” newly started. When I murmured this key word “Teeth are our organs”, a dark labyrinth was found to be an illusion and I found myself standing at a top of the glorious summit from where I could command a vast plane.

Section 1-2. Teeth are our organs

I hurriedly wrote this article to Chapter 2 in one breath. In my research activities, whenever I opened a door, another door was awaiting me and I dashed with excitement on new questions. Any doors could not be opened easily. For example, the multi-variable analysis on saliva and blood pressure took me about 1 year during which I visited a large-scale computer center located in the campus of Kyushu University almost every day. It seemed to me that this research to scientifically prove the correlation between teeth and systemic functions would appear like an uncultivated dark jungle whereby I could not proceed easily. However, I stepped forward steadily.
When I stepped forward in a deep jungle, most of the observed facts could not be explained by the currently available medical paradigm but were conflicting mutually. How does the so-far existing definition about teeth “Functions of teeth exist on chewing foods as a part of digestive organs” permit us to explain the facts which were discovered in this jungle, such as “the correlation between teeth and salivary secretion” and “relationship between teeth and blood pressure”? Furthermore, the discovered facts tell us that individual tooth is responsible for the emitting function of the information to the brain individually. One of the followings might be wrong, either the existing medical paradigm that we were taught in the medical education curriculum, or the facts I discovered during my research. However, my research started from a simple question “Are teeth really necessary for maintenance of human health?” but not from an eye-catching research objective such as “To clarify the correlation between teeth and systemic functions”. While respecting each fact and recognizing my own limitation, I asked for advices and recommendations of specialists of other fields than dental research. During the research, I scientifically proved respective evidences and I reached this stage. Accordingly, there is no possibility that the research findings so far explained in this book would be mistakes.
As a natural consequence, the medical paradigm which was taught in my university days turns out to be wrong. If so, then another question comes to our minds, “What are teeth on the earth?”. I was quite at a loss at this stage. What’s worse, the existing medical paradigm does not work at all in this labyrinth although such a paradigm was used as a compass or the reliable chart. What shall I do? Another question came to my mind.
This puzzle was unexpectedly solved. One day, I had a chattering with an internist with whom I got acquainted in a hotel lounge-bar in front of Hakata Station in Fukuoka city. At that occasion, fortunately I had a slide shown in Figure 30 in my bag. Since I was always asking to myself “What are teeth?” in those days, I showed the slide to him just as a topic of conversation, while saying “I have some interesting data regarding teeth”. After looking the slide for a moment, he murmured a word “Oh, teeth are our organs”.
“-------!“
At that occasion, something sparkled in my head.“Oh, yes. Teeth are our organs!” I shouted with my fingers being closed into a fist.

Section 1-1. Each tooth exhibits different influences on blood pressure

Based on the close correlation between salivary secretion and teeth, we advanced the hypothesis that teeth are involved in autonomic nervous system functions. Subsequently, we clarified the relationship between “Blood pressure” as one of the systemic factors and teeth whereby we could sustain this hypothesis. In the previous Chapter, such an explanation was made but there still remains another theme to be confirmed. As briefly described in the articles related to salivary secretion functions, there is another issue whether any contrary stimulating system corresponding to sympathetic and parasympathetic nerves in the autonomic nervous system might exist or not. In terms of blood pressures, there seems to be contrary effects in teeth based on the equation model obtained from determination of blood pressures; however, we wish to investigate part-specific influences according to kinds of teeth from the view point of the relationship between teeth and blood pressures. Are there any antagonizing effects or harmony in the blood pressures according to kinds of teeth as was observed in investigation of salivary secretion?
Figure 30 illustrates the correlation between kinds of teeth and blood pressures which were calculated during the multi-variable analysis on the blood pressures depicted in the previous chapter. This figure shows the fact that each tooth exhibits individual influences on blood pressures to control them. In the submaxillary part, first bicuspid and third molar contribute to elevation of blood pressures. The canine tooth tends to lower the blood pressure instead. The medial incisor, lateral incisor, second bicuspid and first and second molar teeth seem to exhibit neutral effects. On the contrary in the maxillary part, canine and the first bicuspid have blood pressure increasing effects whereas on the contrary, the second molar seems to lower the blood pressure. In the similar manners as those in the submaxillary part, medial incisor, lateral incisor, the second bicuspid and the first molar teeth tend to exhibit neutral actions. The data lines for the teeth, the maximum blood pressure and the minimum blood pressure in Figure 30 were calculated independently; however, beautiful coincidence of the trend according to kinds of teeth indicates high reliabilities of the obtained results. As was the same with the results obtained in salivary secretion functions, blood pressures are affected by individual tooth differently. Furthermore, such effects were found to be contrary or antagonistic as was found in the autonomic nerve functions.



Figure 30
Correlation between teeth by their kinds and blood pressure
These graphs show the correlation between individual submaxillary teeth and blood pressures which were calculated during the multi-variable analysis. The figures from 1 to 8 shown on the horizontal axis denote, (1) medial incisor, (2) lateral incisor, (3) canine, (4) first bicuspid, (5) second bicuspid, (6) first molar, (7) second molar, and (8) third molar. On the vertical axis, the upper column shows the systolic blood pressures, with the lower column for the diastolic blood pressures. Furthermore, please understand the followings while reading these graphs. There is a reference line at the point of 0. The blood pressures below this line mean that the blood pressure shall be lowered by stimulation of teeth whereas on the contrary, the blood pressures above this line indicate that the blood pressure shall be increased by stimulation of teeth. This suggests that individual tooth exerts different influences on blood pressures; as explained in +,－signs for teeth variables in the model equation, influences by individual tooth are not homogeneous but they change blood pressures independently. In terms of submaxillary teeth, both submaxillary first bicuspid (4) and third molar (8) tend to elevate blood pressures while the canine (3) lowers blood pressures. In the similar manners, please look at the maxillary teeth. It would appear likely that both canine and first bicuspid increase blood pressures. On the contrary, second molar seems to decrease the systolic blood pressure. In these graphs, the data lines for teeth as well as systolic and diastolic blood pressures were separately calculated; however, beautiful consistency in trends of teeth provide us with confidence of good reliability.

Section 4-3. Proof by multi-variable analysis. Teeth actually affect blood pressure

Decision of the equation model concerning blood pressures was conducted by the systemic factors as shown in Figure 9 as was the same with salivary secretion. Figures 25 and 26 show both systemic and diastolic blood pressures in the subjects with more than 13 teeth; however, the risk rates (P value) of their errors were 0.0001 indicative of a highly reliable equation model. In both cases, 7 factors were selected as the descriptive variables but it was proved that teeth played an important role in both systolic and diastolic blood pressures.
The teeth selected as influential teeth were submaxillary first bicuspid and third molar tooth, maxillary canine and second bicuspid, maxillary first bicuspid, first and second molar teeth. To be noted is the fact that “―” signal in the model equation indicates the following general trend such as teeth elevating blood pressure but maxillary second bicuspid and second molar tooth lowering blood pressure. These interesting findings led us to recognize the key notion “Teeth are our organs”; however, details shall be described later. It is noteworthy that the third molar tooth (wisdom tooth) is deeply involved in elevation of blood pressure. According to the common sense in the dental field, the wisdom tooth is useless but on the contrary, it seems to us that this tooth might play an important role in maintaining vitality and vigor of humans. In hypertensive patients, there is a possibility that continuous and too strong stimulation is given to the teeth conducive to increasing blood pressure such as the wisdom tooth, maxillary first bicuspid, first molar and canine as well as submaxillary first bicuspid and second bicuspid, or weaker stimulation is given to maxillary second molar and second bicuspid which lower blood pressure. In hypotensive patients, we can anticipate that hypotension is induced by the contrary mechanism related to the above-stated teeth. This is a key theme related to the organic features of teeth, and accordingly, this shall be referred to below in details. This would appear likely to imply extremely important issues.
Figures 27 and 28 show the equation model regarding the maximum and the minimum blood pressures in the cases with less than 15 teeth.
In terms of the minimum blood pressure, we obtained 0.9 as the multiple correlation coefficient, 0.81 as the contribution ratio and 0.0002 as the risk ratio P, all of which suggests extremely high reliability, indicating that teeth play an important role in the diastolic blood pressure. The selected teeth were maxillary medial incisor and submaxillary canine tooth. These teeth seem contributory to decrease of blood pressure.
As briefed above, the order of teeth to be lost is maxillary and submaxillary molar, bicuspid, maxillary canine and front teeth, and finally submaxillary canine and front teeth, in this loosing order. This means that the subjects with less than 15 teeth hardly have molar teeth. In the equation model concerning the maximum blood pressure, the contributory ratio indicative of power of explanation is 0.42; this means that if the complete explanation by this model is regarded as 100, only 42% can be explained. This indicates that in addition to the stipulated explanatory variables, there might exist more influential other factors. In any events, when the remaining teeth become less in number, the influential power of teeth on the maximum blood pressure is negligible. This phenomenon is attributed to absence of the teeth influential to the blood pressure due to extraction.
The results obtained by the above-stated multi-variable analysis verified that teeth provide influences on the blood pressure without any influences of the systemic background factors and furthermore, the influences of teeth are so decisive to control the blood pressure in comparison with other systemic factors. This is an epoch-making discovery　because the total population under treatment of hypertension is estimated to amount to more than 10 million in Japan. If candidates with border-line hypertension and latent hypertension are included, more than 2 to 3-fold population, namely approximately 30 % of Japanese people are suffering from hypertension. As is well known, hypertension is classified into secondary hypertension of which causes are clarified and essential hypertension characteristic of unknown causes whereas more than 90 % of the patients belongs to the latter essential hypertension. Despite of remarkable progress of medical researches, actual causes of this important disease from which more than 30 million people are suffering have not yet been clarified, suggesting that there might be unexcavated blind points as the research fields. I am now confident that teeth would be responsible for this disease. Shall we review individual testimony from patients which surely convince us of our above-stated confidence?
I was suffering from hypertension for about 10 years. In April 1993, plates were implanted at Muratsu Clinic to correct irregular bites. As the results, the diastolic blood pressure was lowered to 80s mmHg, with the systolic blood pressure decreasing to 130s mmHg. Subsequently, my blood pressures have been continuously stable. (64 years old, male, Fukuoka)
This patient had received treatment of hypertension in the Kyushu University Detached Hospital. Judging from his age, it was very rare to have his own teeth under a relatively complete condition. As shown in his memo, he was diagnosed to have hypertension about 10 years ago and he took the prescribed anti-hypertensive agents; however, his hypertension was not improved, resulting in continuously persisting. However, immediately after treatment of abnormal occlusion, efficacy was promptly observed to show blood pressure decrease down to the normal healthy levels (Figure 29). You can find sudden decrease of blood pressure immediately after commencement of occlusion treatment from this figure.
This fact corroborates that teeth are responsible for onset of persisting hypertension. These data had been independently stored as the record of his blood pressures in a hospital where he received medications; however, he kindly brought these data to us because he was so pleased of improvement of hypertension by our dental treatment. Before and after out dental treatment, no alterations of prescribed drugs including combined use with other drugs were made. He is still continuing his preventive cares at our KOS clinic but no relapse of hypertension is observed.
Next witness comes from a female patient who showed improvement of hypotension and systemic health conditions following recovery of dental health. Coupled with testimony of her son, this letter surely makes you recognize the fact that teeth provide influences not only blood pressure, autonomic nerve but also systemic conditions.

Since my childhood, I was always suffering from some diseases. When I
was 19 years old, I suffered from Basedow's disease and I felt some anxiety;
furthermore, I was so nervous about health and whenever tiny abnormality was
perceived, I became depressed. Under such conditions, I got married and
gave birth to a child. Although I was susceptible to diseases, I kept
working very hard. Under such situations, I was introduced by my
elder brother to Dr. Muratsu and I received the dental treatment and gradually,
I recognized that my health was recovered. Very tiny improvements occurred
including stepping up high stairways, easily walking in a bustled area and
disappearance of stiff shoulder and eye ball pains.
Significant changes were found in blood pressures. Before treatments,
I was suffering from hypotension with the systolic blood pressure of 87 mmHg and
as the maximum up to 95 mmHg even during pregnancy. I was not so nervous
about lowered blood pressures because I had been accustomed to hypotension but
after completion of the dental treatment, I happened to know elevation of the
systolic blood pressure to 110～120 mmHg. I could not find out any other
causes except treatment of teeth. I was surprised at this change because I
had considered that hypotension could not be cured.
My son also received treatment of rhinitis. He always sniffled but
immediately after dental treatment, he appeared without any sniffling from Dr.
Muratsu’s office. He had had very nervous characters previously but
recently, this feature was improved. When he became a fourth grade
elementary school child, he entered an extracurricular club. Dr. Muratsu,
I really appreciate your kind treatment so that all of our family members are
confident about our health.
(41-year-old woman, Kumamoto)

This patient had a partial irregular occlusion in the front part which should be treated by means of prosthetic correction methods.


Figure 25
Equation model of systolic blood pressure (1)
(Current No. of teeth: ≧13 teeth)
------------------------------------------------------
Systolic blood pressure = 157
+13.1 X Submaxillary third molar
+16.3 X Maxillary first bicuspid
+5.1 X Maxillary first molar
－10.8 X Maxillary second molar
－0.44 X pulse rate－21.6 X Albumin/globulin ratio
+2.6 X Ca amount
------------------------------------------------------
Multiple correlation coefficient=0.8
Contribution ratio =0.65
P value＜0.0001
This is the equation model for systolic blood pressure (General linear multiple regression model) in the cases with more than 13 teeth as the current residual number of teeth. The multiple correlation coefficient indicating the degree of correlation was 0.8, with the contribution ratio indicative of power of explanation being 0.65, and the p value indicative of the statistical significance being 0.0001. All of them suggest that the scientific credibility is extremely high. The fact that the dental factors are selected as the explanatory variables on the right-hand side means that teeth are involved in systolic blood pressure. Particularly, maxillary first bicuspid, first molar, second molar and submaxillary wisdom tooth seem to be implicated.


Figure 26
Equation model of diastolic blood pressure (1)
(Current No. of teeth: ≧13 teeth)
------------------------------------------------------
Diastolic blood pressure = 14.7
+7.96 X Submaxillary first bicuspid
+4.99 X Submaxillary third molar
+7.95 X Maxillary canine
－4.03 X Maxillary second bicuspid
+0.81 X Age
－0.01 X Noradrenaline level
+0.11 X HDL cholesterol level
(Medical items are obtained from the serum.)
------------------------------------------------------
Multiple correlation coefficient=0.89
Contribution ratio =0.79
P value＜0.0001
This is the equation model for systolic blood pressure in the cases with more than 13 teeth as the current residual number of teeth. The multiple correlation coefficient was 0.89, with the contribution ratio being 0.79, and the p value being as small as 0.0001. All of them suggest that the scientific credibility is extremely high. The fact that the dental factors are selected as the explanatory variables on the right-hand side means that teeth are involved in diastolic blood pressure. Particularly, maxillary canine, second bicuspid, submaxillary bicuspid and wisdom tooth seem to be deeply implicated.


Figure 27
Equation model of systolic blood pressure (2)
(0＜Current No. of teeth: ＜15 teeth)
------------------------------------------------------
Systolic blood pressure = －197
+25.2 X Total protein amount
－0.14 X Triglyceride level
+5.1 X Noradrenaline level
+0.003 X Na level
------------------------------------------------------
Multiple correlation coefficient=0.65
Contribution ratio =0.42
P value＜0.02
This is the equation model for systolic blood pressure in the cases with less than 15 teeth as the current residual number of teeth. Both the multiple correlation coefficients and the contribution ratio were low, with the p value being high. All of them suggest that this equation model is not credible. In addition, factors related to teeth are not included therein. It postulated that any other factors than the selected factors for this equation might be strongly involved.


Figure 28
Equation model of diastolic blood pressure (2)
(0＜Current No. of teeth: ＜15 teeth)
------------------------------------------------------
Diastolic blood pressure = －13.2
－4.77 X Maxillary medial incisor
－7.77 X Sub maxillary canine
+13.5 X Albumin level
+23.3 X Mg level
－1.45 X Ca level
+0.009 X Noradrenaline level
------------------------------------------------------
Multiple correlation coefficient=0.90
Contribution ratio =0.81
P value＜0.0002
This is the equation model for diastolic blood pressure in the cases with less than 15 teeth as the current residual number of teeth. The multiple correlation coefficient was 0.90, with the contribution ratio being 0.81, and the p value being as small as 0.0002. All of them suggest that the scientific credibility is extremely high. It seems that teeth are implicated. In particular, with less residual sub maxillary teeth, stronger influences of maxillary medial incisor and sub maxillary canine are observed.



Figure 29
An example in which treatment of abnormal occlusion alleviated hypertension
Previously, this patient had 152mmHg as the mean systolic blood pressure, 94 mmHg as the diastolic blood pressure, indicating persisting hypertensive situation. Immediately after commencement of occlusion treatment, blood pressures were reduced such as 130 mmHg as systolic blood pressure and 80 mmHg as diastolic blood pressure.

Section 4-2. Correlation between teeth and blood pressure by the correlation line

Taking into account the fact that the maximum blood pressure (systolic blood pressure) is variable due to influences of various factors, I investigated the correlation between the minimum blood pressure (diastolic blood pressure) and the current number of teeth in accordance with the recommendation by an internist, one of our co-researchers.
Figure 19 shows the results obtained. Simultaneously, a statistician, one of our co-researchers was asked to analyze this result, whereby it was revealed that as shown in the correlation line, there was a folding point around the current number of 13～15 teeth, and the subjects could be assigned into the following three groups; the subjects with more than the number of teeth at the folding point, the subjects with less than the teeth at the folding point and the subjects with no teeth. In these three groups, there was an inflexion point at the border of each classification, suggesting presence of some systematic qualitative difference among these groups.
Figures 20 and 21 provide the distribution of both systolic and diastolic blood pressures in the subjects with more than the number of teeth at the folding point. Both of these figures show positive correlation, indicating that with increase of the current number of teeth, blood pressures become higher.
For your better understanding, the mean blood pressures were compared between the subjects with more than 20 teeth and those with less than 19 teeth. As shown in Figure 22, the subjects with more than 20 teeth scientifically showed higher values both in systolic and diastolic blood pressures.
Next comes the distribution patterns of systolic and diastolic blood pressures in the subjects with less than the teeth number at the folding point (Figures 23 and 24). On the contrary to those beyond the folding point, however, negative correlation was found between the present number of teeth and both systolic and diastolic blood pressures; this indicates that with increased number of the present teeth, blood pressures are decreased. In the subjects without own teeth, the systolic blood pressures were ranging from 95 mmHg to 158 mmHg with the diastolic blood pressures being distributed from 54 mmHg to 83 mmHg.
Thus, the correlational analysis between the current number of teeth and blood pressures disclosed for the first time presence of correlation of teeth with the blood pressures which had not been even suspected. However, blood pressures are susceptible to individual difference factors of the subjects such as ages and systemic background factors including body weight, plasma triglycerides and plasma cholesterol. Accordingly, as is the same with salivary secretion functions, all we have to do is to verify the real influences of teeth on blood pressures following more careful elimination of influences of background factors.
We promptly started studies to confirm the correlation of the two factors between teeth number and blood pressures by using the multi-variable analysis, with the cooperation of internists and statisticians. If teeth as the factor providing obvious influences on blood pressures can be confirmed by multi-variable analysis, we can declare decisive relationships between teeth and autonomic nerves.
In more details, most of the front teeth must be ground to improve the direction of each tooth. At the age of 19 years old, Basedow's disease occurred and since then, she felt fears of her health; however, probably, all of these anxieties stemmed from dental problems. In addition to this case, there are lots of patients whose symptoms related to hypertension or hypotension were alleviated in parallel with recovery of their dental health. As is obvious from these cases, we can say that teeth are clinically associated with blood pressures.



Figure 20
Correlation between the maximum blood pressure (systolic blood pressure) and the current number of teeth (more than 13 teeth) by the correlation line
There was a positive correlation between the residual pattern of teeth and the systolic blood pressure. In other words, loss of teeth results in reducing the blood pressure.



Figure 21
Correlation between the minimum blood pressure (diastolic blood pressure) and the current number of teeth (more than 13 teeth) by the correlation line
There was a positive correlation between the residual pattern of teeth and diastolic blood pressure. In the similar manners as the systolic blood pressure, loss of teeth results in reducing the blood pressure.



Figure 22
Influences of teeth on blood pressures
When the mean blood pressure was investigated in the subjects either with more than 20 teeth as the current residual number or with less than 19 teeth, the subjects with more than 20 teeth left obviously showed higher blood pressure.



Figure 23
Correlation between the maximum blood pressure (systolic blood pressure) and the current number of teeth (≦15 teeth) by the correlation line
There was a negative correlation between the residual pattern of teeth and systolic blood pressure. In other words, loss of teeth results in increasing the blood pressure.



Figure 24
Correlation between the minimum blood pressure (diastolic blood pressure) and the current number of teeth (≦15 teeth) by the correlation line
There was a negative correlation between the residual pattern of teeth and systolic blood pressure. In other words, loss of teeth results in increasing the blood pressure.

Section 4-1. Do teeth affect blood pressure? Proof of the correlation with autonomic nervous system

If the hypothesis “Teeth are involved in the autonomic nervous functions” which was explained in the previous chapter is really correct, we can anticipate that signals relating to chewing stimulation would affect not only secretion of saliva as the local effect but also provide systemic influences. So as to sustain this hypothesis, we focused our attention on the factor, namely the blood pressure which is significantly affected by systemic and autonomic nerves.　　If this hypothesis is correct, the blood pressure should be also changed. Unless similar changes as did saliva are found in the blood pressure, we can conclude that influences of teeth on secretion of saliva must be local ones and they could not be the systemic influences in which autonomic nerves are involved. However, presence of similar changes in the blood pressure as did secretion of saliva eventually proves the said hypothesis that teeth are implicated in autonomic nervous system.
Upon pursuing the correlation between teeth and blood pressure, the interdisciplinary features of this research project played a significant role. Unless this project provides broader information covering other fields in addition to dental profiles, I am afraid that the study on teeth could not have been completed and furthermore, I failed to recognize the said “Teeth-organ theory” and eventually this book would not have been published. As the results, my life has been probably changed.
In the previous Chapters, I briefly explained the process by which I recognized the correlation of teeth with blood pressure. Frankly speaking, the hypothesis that teeth are involved in the central life function such as autonomic nerves would appear incredible from the viewpoint of conventional dental common senses. However, I ventured into an uncultivated world to destroy and revise the existing medical paradigm, which has not been challenged by dental researchers in the past. To tell the truth, I had emotional conflict over sticking to the established paradigm and unexpected internal resistance against continuing this research. For example, when I was engaging in input of the blood pressure data for statistical analysis into a computer at night, my body and fingers showed rejection responses contrary to my will, with some doubts “I really wonder whether I am trying to do some foolish and unnecessary tasks”. Triggered by the word “Doctor, I can bite any food” by an old woman wearing dentures, I have opened the way so far but I was wondering where I could find the final destination, namely the goal for this research. I was puzzled by these questions and quite at a loss. However, now that I came from the very beginning all the way, I could not stand still at this point. All I have to do is to go forward even if I encounter any obstacles. At that time, I was driven by obsession and sense of mission as a researcher, and simultaneously, I felt premonition that extremely important fact can be excavated by this survey.
First of all, I input the available data to a computer where the current number of teeth and the minimum blood pressure (diastolic blood pressure) were placed on the horizontal and the vertical axes on the graph. The software to analyze the correlation was activated. Whenever the correlation between the two relevant factors was assessed, usually the dots were widely scattered on the graph like sky full of stars and the correlation line indicative of the correlation could hardly be observed. In sharp contrast, however, completely different findings were observed at this time. The clear correlation line suddenly appeared on the monitor. That was an incredible sight. I could not help but give a call to an internist, one of the co-researchers even at 1 O’clock in the midnight and I shouted “Obvious correlation exists between teeth and blood pressure!” Despite of having performed our survey, I was so surprised to find the clear correlation between teeth and blood pressure because the involvement of teeth in systemic functions had remained unclear until that time. To tell the truth, I could not believe the graph on the monitor. Nevertheless, the computer display clearly shows the correlation line. I confirmed our findings following input of various relevant data to strengthen them.



Figure 19
Correlation between the minimum blood pressure (diastolic blood pressure) and the current number of teeth by the correlation line
Correlation was observed between the number of the left teeth and the diastolic blood pressure. There was a folding point around the current number of 13～15 teeth, and the direction of the correlation line was changed before and after this folding point.

Section 3-6. Why don’t you play piano with teeth?

The followings are the explanation about influences of each tooth on secretion of saliva. The analysis was performed by using the partial correlation coefficient obtained from multi-variable analysis as the index. Figure 17 illustrates the intentionally expanded row of teeth on upper and lower jaw while influences of each tooth on secretion amount of saliva and protein concentrations are shown with the length of pillars. White pillars denote secretion amount while black pillars show protein concentrations.
Shall we start with secretion amount of saliva shown by white pillars? The order of influences was the strongest in primary and secondary molar, followed by teeth in the anterior part in this decreasing order. How are the protein concentrations? Please look at black pillars in the figure. In sharp contrast with the secretion amount, higher peaks are found in maxillary canine and teeth in anterior part, as well as submaxillary primary bicuspid, with their influences decreasing toward the posterior teeth. These results are quite consistent with the outcomes obtained by the equation models. In more details, loss of bicuspid and the anterior teeth on jaw is associated with reduction or changes of salivary quality whereas loss of posterior teeth is accompanied by vulnerability to decrease in secretion amount of saliva. For your better understanding, shall we confirm it by referring to actually determined values of salivary secretion.Figure 18 shows the actually determined secretion amount of saliva from the following teeth; maxillary first molar as the representative teeth which are heavily involved in secretion amount of saliva; maxillary canine and submaxillary first bicuspid which showed strong influences on protein concentrations; and submaxillary canine which showed equivalent influences on both secretion amount of saliva and protein concentrations. As evidenced in this figure, the teeth indicative of strong influences on secretion amount of saliva and protein concentrations in Figure 17 demonstrated special features in that even a single loss of these teeth resulted in about 2-fold decrease in the actually observed values. On the other hand, the teeth which showed shorter pillars but no biased influences exerted no significant changes in both secretion amount of saliva and protein concentrations even if these teeth were lost. Do you understand these trends?As explained above, secretion of saliva is mainly affected by parasympathetic nerve among autonomic nerve system while protein concentration in saliva is primarily controlled by sympathetic nerve.
If we convert involvement of each tooth to nervous stimulation, we might say that posterior teeth, in particular submaxillary first and second molar and the maxillary first molar easily induce parasympathetic nerve stimulation whereas teeth in the middle part such as maxillary canine and submaxillary first bicuspid as well as maxillary anterior teeth cause sympathetic nerve stimulation. As the next step, you are asked to visualize the curves which are plotted by connecting the tops of white and black pillars. You will find a beautiful wave pattern woven by both curves which resembles an alternating electric curve. It seems to us as if individual tooth generates slightly different continuous tones which create a beautiful harmony. To be noted is the fact that 8 teeth starting from central incisor to the third molar in the posterior part constitute one unit, corresponding to one octave in the musical scale. This unit is associated with the basic structure of brain and it is easy for us to understand that there might be the transmission system of information comparable to do, re, mi, fa, sol, la, and ti, from anterior teeth to posterior teeth. In fact, chewing food with our teeth can be represented by hitting keyboards in brain with teeth like playing piano and playing music with our body when taking into account the transmission system of information with our teeth to brain. Although there is no difference in the music scales by individual tooth keyboard, foods to be chewed are responsible to alteration of tone timbre. Imagine varieties of foods such as bamboo shoots, devil’s tongue, rice cracker, soybean curd, rice, apples, herring roe, pickled radish and the like, and you could understand that various kinds of tone timbres are available on the earth. Meals can be compared to orchestrated music, in a sense, comprising of trumpet, violin, tuba, harp and timpani.
Dining is filled with lots of joyful sounds including food stuffs comparable to sounds from various kinds of musical instruments, “tastes and cold/warm sensation”, “flavor”, “beautiful harmony of arranged food layout”, “thoughtfulness by the host”, and “conversation on food”. Dining can be compared to an orchestra while teeth play a role as the concert master. You are the conductor. So as to offer actual experiences of the tone images by teeth to you, we have already prepared the relevant CD with the title of “Lets play the piano with teeth keyboards – Secrets of Teeth –“. This CD was prepared with the objective of having children recognize that every tooth is an indispensable living organ, thereby contributing to propagation of a life-long campaign to stimulate teeth health of them. This has been extensively employed as the educational material for elementary and middle schools. If you are interested in it, please have a contact with KOS.We have reviewed the correlation of teeth with autonomic nervous system whereby we are confident of the possibility of teeth influences on autonomic nervous systems in various aspects. Our survey of the relationship between teeth and health in vivid elderly persons happened to advance the following hypothesis “Teeth are involved in autonomic nervous system”. Thus, close correlation between teeth and autonomic nervous system has been verified during the course of investigating the relationship of teeth with secretion function of saliva; in this connection, however, another issue directly implicated in secretion of saliva has secretly occurred. If you will find this issue, you can recognize that the aforementioned hypothesis would not miss the mark. May I explain it in details as follows?Its is a dry mouth. Recently, about one out of four Japanese is suffering from xerostomia or its related symptoms. I anticipate that some of the readers of this book might be suffering from dry mouth and often lick the throat drops. These persons predispose to occurrence of decayed teeth particularly at the interface between teeth and therefore, a relevant term, “Throat-drop syndromes” is coined to denote such situations. In this connection, about 40 percents of elderly persons complain about dryness of their mouths, indicating a serious problem among them.Xerostomia mainly observed in elderly persons throughout Japan is caused by loss of teeth and abnormal occlusion which also occur nationwide. With advancing age, teeth are extracted in such a manner as 5 teeth in 50s, 10 teeth in 60s and 17 teeth in 70s in an average. In the former half of 80s of age, only 7 teeth are left (Reference 39), suggesting that 21 teeth are extracted. Since teeth are lost from the more posterior parts, this means that more parasympathomimetic teeth are tended to be removed earlier. As explained before, the parotid gland which secretes serous saliva is controlled by parasympathetic nerve to secrete saliva. Accordingly, if posterior teeth are lost, anterior teeth and bicuspids characteristic of mainly exhibiting sympathomimetic properties remain, leading to augmented function of submaxillary gland and secretion of viscous saliva. As the result, inside of the oral cavity becomes sticky, resulting in stimulating dry sensation within the cavity. It is quite natural for these persons to want to lick throat drops. Although elderly persons abandon their pursuit of ample secretion of saliva because of aging, xerostomia is not attributed to aging but is due to problems related to their teeth. Nobody can revive lost teeth but improvement of abnormal occlusion is sometimes associated with adequate secretion of saliva. It is anticipated that satisfactory chewing simultaneously improves internal transmission of information from teeth. Shall we review actual examples of such representative patients as follows?

Before treatment, I was suffering from dry mouth, unpleasant feeling of less
secretion of saliva, and tongue pains. Therefore, these symptoms always made me
gloomy. Since correction of abnormal occlusion and removal of silver
implantation by Dr. Muratsu, ample amount of saliva has been secreted into mouth
and I felt comfortable.
(52-year-old woman, Saga)

Incidentally, this patient has completed the scheduled treatment. Xerostomia observed at her initial consultation has already been eliminated with her heath being recovered, and currently, she spends a happy life since then.



Figure 17
Influences of each tooth on secretion amount of saliva and protein concentrations
Levels of influences are shown by the length of pillars.
The secretion amount of saliva seems to be affected by the posterior molars, in particular, submaxillary primary and secondary molars, and the maxillary first molarThe protein concentrations seem to be most affected by the front teeth. In particular, the submaxillary first bicuspid, maxillary first bicuspid, canine, lateral incisor and middle incisor most notably affected the protein concentrations.

Section 3-5. Teeth-dependent excitation system and spiritual comfort system

As you might know, autonomic nervous system is consisted of two kinds of nerves, namely sympathetic and parasympathetic nerves. Sympathetic nerve is responsible for transmission of excitatory information while parasympathetic nerve exerts comfortable properties, both of them playing a role in the basic transformation of information supportive of the vital activities. If we compare them to music, sympathetic and parasympathetic nerves share the jobs to control daily vital activities thereby attaining the overall harmony. We wonder whether teeth shall make timely and appropriate judgment in order to correspond to the contrary two different nerve stimulations or not. Otherwise, is only homogenous influence providing irrespective of different shapes of teeth or different locations of teeth?
Once again, shall we review the model equations concerning secretion amount of saliva (Figure 10) and protein concentrations (Figure 10) which were obtained by multi-variable analysis. Names of teeth as the explanatory variables on the right-hand side of equation for secretion amount of saliva were submaxillary second molar, maxillary first and second bicuspid, maxillary first molar, and second molar. On the other hand, names of teeth as the corresponding variables for protein concentrations were maxillary canine, submaxillary first, second bicuspid and first molar, indicating different teeth involved; furthermore, +, －signals on top of them were also different mutually. For you better understand, you are kindly asked to note that ＋signal indicates increase in the values of the objective variables for either secretion amount or protein concentrations on the left-hand side of equation while －signal means decrease of these parameters. Namely, locations of teeth seem to show different influences. Based on such a hypothesis, we decided to determine the influences on salivary secretion according to locations of teeth. Teeth including wisdom tooth have 8 teeth each on upper jaw, amounting to 16 teeth while the lower jaw has 16 teeth, reaching 32 teeth in total. Names of respective teeth were three teeth in anterior part such as medial incisor, lateral incisor and canine tooth; two teeth in bicuspid teeth such as first and second bicuspid; and three teeth in molar teeth such as first, second and third molar teeth (wisdom tooth). Accordingly, teeth were divided into three parts such as teeth in anterior part, bicuspid part and molar teeth, followed by investigating influences of loss of teeth on secretion of saliva and protein concentrations.
Figure 14 shows such influences according to respective parts by figures. Coefficient of correlation indicates the correlation between the residual patterns of teeth and secretion amount of saliva while the lower the figures the closer the correlation is. The risk rate means scientific credibility of the figures representing the coefficient of correlation. The smaller the figures the higher the credibility is. For example, if the error probability is less than 5% (P<0.05), the data are considered to be reliable. Complicated figures would be difficult for you to understand the outlines and therefore, I would like to show you the figure which clearly illustrates the correlation between the locations of teeth and secretion of saliva.
Looking at the secretion amount of saliva (Figure 15) and protein concentrations (Figure 16), you might note completely contrary a trend between them.
In other words, the more posterior the higher the secretion amount is affected whereas the more anterior the higher the protein concentrations are affected. There might be a possibility that individual tooth provides different transmission types of information to brain in similar manners as different shapes of respective teeth. It is interesting to pursue what kinds of differences exist per each tooth.
Influences of teeth by areas on the salivary protein concentrations




Figure 14
Correlation between the residual patterns of teeth by areas and secretion amount of saliva as well as protein concentrations
The correlation coefficients indicate significance of influences. The bigger figures, the stronger influences. P value stands for the level of the error probability. The smaller the figures the higher the credibility is. * denotes the error probability. When it is less than 0.05, it can be considered that there is a statistical “Significance”.



Figure 15
Influences of teeth by areas on the salivary secretion amount
Lower teeth affected the salivary secretion amount more than upper teeth did. The more posterior, the higher the secretion amount is affected.





Figure 16
Influences of teeth by areas on the salivary protein concentrations
Upper teeth affected the salivary features (protein concentrations) more than lower teeth did. The more anterior, the higher the salivary features are affected.